Photoaccentuated erythroderma associated with CD4 + T lymphocytopenia: Successful treatment with 5-methoxypsoralen and UVA, interferon alfa-2b, and extracorporeal photopheresis

We describe a 53-year-old HIV-negative white man who had chronic CD4 + T lymphocytopenia and photoaccentuated erythroderma with lymphoma-like histologic changes. The erythroderma completely responded to 5-methoxypsoralen and UVA (PUVA), interferon alfa-2b, and extracorporeal photopheresis. During th...

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Veröffentlicht in:Journal of the American Academy of Dermatology 1996-08, Vol.35 (2), p.291-294
Hauptverfasser: Wolf, Peter, Müllegger, Robert, Cerroni, Lorenzo, Aigner, Reingard, Fueger, Gerhard, Höfler, Gerald, Derbaschnig, Johann, Kerl, Helmut
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Sprache:eng
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Zusammenfassung:We describe a 53-year-old HIV-negative white man who had chronic CD4 + T lymphocytopenia and photoaccentuated erythroderma with lymphoma-like histologic changes. The erythroderma completely responded to 5-methoxypsoralen and UVA (PUVA), interferon alfa-2b, and extracorporeal photopheresis. During therapy opportunistic skin infections, including tinea corporis, warts, and disseminated molluscum contagiosum, developed. Although the patient met the current definition of idiopathic CD4 + T lymphocytopenia (ICTL), we cannot rule out the possibility that his peripheral CD4 + T lymphocytopenia resulted from sequestration of CD4 + T lymphocytes in erythrodermic skin.
ISSN:0190-9622
1097-6787
DOI:10.1016/S0190-9622(96)90651-9