Comparison of Eltanolone and Propofol on a Pressure-Volume Analysis of the Heart

We designed a randomized study to compare the effect of eltanolone and propofol on cardiac contractility.Patients were anesthetized, tracheally intubated and ventilation controlled. Propofol, 1.25 or 2.5 mg/kg, or eltanolone, 0.5 or 1 mg/kg, or a lipid emulsion only was administered in an intravenou...

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Veröffentlicht in:	Anesthesia and analgesia 1996-08, Vol.83 (2), p.233-237
Hauptverfasser:	Mulier, J. P., Van Aken, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthetics, Intravenous - administration & dosage Anesthetics, Intravenous - pharmacology Anesthetics. Neuromuscular blocking agents Biological and medical sciences Blood Pressure - drug effects Blood Volume - drug effects Cardiac Volume - drug effects Depression, Chemical Echocardiography, Transesophageal Fat Emulsions, Intravenous - administration & dosage Female Humans Hypnotics and Sedatives - administration & dosage Hypnotics and Sedatives - pharmacology Intubation, Intratracheal Medical sciences Myocardial Contraction - drug effects Neuropharmacology Pharmacology. Drug treatments Pregnanolone - administration & dosage Pregnanolone - pharmacology Propofol - administration & dosage Propofol - pharmacology Radial Artery Respiration, Artificial Ventricular Function, Left - drug effects Ventricular Pressure - drug effects
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Zusammenfassung:	We designed a randomized study to compare the effect of eltanolone and propofol on cardiac contractility.Patients were anesthetized, tracheally intubated and ventilation controlled. Propofol, 1.25 or 2.5 mg/kg, or eltanolone, 0.5 or 1 mg/kg, or a lipid emulsion only was administered in an intravenous (IV) bolus dose. Pressure-volume analysis was used based on radial artery pressure and transesophageal left ventricular cross-sectional area. Both propofol and eltanolone have negative inotropic properties in humans. We conclude that equianesthetic doses of these drugs produce similar changes in myocardial contractility.(Anesth Analg 1996;83:233-7)
ISSN:	0003-2999 1526-7598
DOI:	10.1097/00000539-199608000-00006