Levels of Nitric Oxide Correlate with High Levels of Tumor Necrosis Factor α in Cerebrospinal Fluid Samples from Children with Bacterial Meningitis

Little is known about the role of NO (nitric oxide) in the pathophysiology of bacterial meningitis. In vitro studies have shown that the production of NO can be induced by TNF. High levels of TNF in the CSF correlate with the development of neurological sequelae. The aim of the present study was to assess whether levels of NO in CSF correlate with levels of TNF and with other inflammatory parameters in the CSF samples of children with bacterial meningitis.