The association between lung innate immunity and differential airway antigen- specific immune responses

The mechanisms involved in the differential regulation of airway immune responses in atopic versus non-atopic individuals are poorly understood. In this study, the association between non specific immunity and the differential airway antigen-specific Immune responses was examined in a murine model. The disparity In antigen-specific IgE and IgG2a productions between the two strains of mice was observed to be significant. C57BL/6J mice were much more efficient than BALB/cJ mice in making IgE antibody to Inhaled ovalbumin (OVA) antigen. On the contrary, BALB/cJ mice did make more IgG2a antibodies than C57BL/6J mice to Inhaled OVA. These findings suggest that in C57BL/6J mouse strain a predominant Th 2 type of Immune response develops in response to inhaled OVA antigen. In contrast, BALB/c mice mount a Th 1 type of immune response to aerosollzed OVA antigen. Furthermore, after lipopolysaccharlde (LPS) stimulation, the IL-12 mRNA expression of lung-derived cells from BALB/cJ mice was higher than that from C57BL/6J cells. However, the lung-derived cells of C57BL/6J mice stimulated by LPS produced higher levels of IL-b and prostaglandin E than BALB/cJ lung-derived cells did. Therefore, our study demonstrated that the difference of lung-derived cells in their ability to produce cytokine and prostaglandln between BALBIcJ and C57BL/6J mice correlates well with the type of the airway antigen-specific immune effector functions.