Use of liposome‐associated bupivacaine in a cancer pain syndrome

Summary Bupivacaine. 0.25% encapsulated by multilamellar liposomes was administered epidurally to a patient suffering pain associated with lung cancer and the effect compared with a plain bupivacaine solution of the same concentration. Complete analgesia was produced for 4 h with the plain solution...

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Veröffentlicht in:	Anaesthesia 1996-06, Vol.51 (6), p.578-579
Hauptverfasser:	Lafont, N. D., Legros, F. J., Boogaerts, J. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anaesthetic techniques regional epidural Anaesthetics, local bupivacaine Analgesia, Epidural - methods Anesthetics, Local - administration & dosage Anesthetics. Neuromuscular blocking agents Biological and medical sciences Bupivacaine - administration & dosage Drug Carriers Humans Liposome drug association Liposomes Lung Neoplasms - complications Medical sciences Neuropharmacology Pain, Intractable - drug therapy Pain, Intractable - etiology Pharmacology. Drug treatments Syndrome
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Beschreibung
Zusammenfassung:	Summary Bupivacaine. 0.25% encapsulated by multilamellar liposomes was administered epidurally to a patient suffering pain associated with lung cancer and the effect compared with a plain bupivacaine solution of the same concentration. Complete analgesia was produced for 4 h with the plain solution and 11 h with the liposomal formulation. No motor blockade or haemodynamic instability was observed with the liposome‐associated bupivacaine.
ISSN:	0003-2409 1365-2044
DOI:	10.1111/j.1365-2044.1996.tb12569.x