The secretor locus as a marker for prenatal prediction of myotonic dystrophy (DM)

The secretor locus as a marker for prenatal prediction of myotonic dystrophy (DM)

To verify the reliability of secretor status for prenatal diagnosis of myotonic dystrophy (DM), 179 amniotic fluid samples were compared with saliva or urine samples of the infants by hemagglutination inhibition. While no discrepancies were observed, problems could arise with intermediate results. A...

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Veröffentlicht in:Human genetics 1988-04, Vol.78 (4), p.330-332
Hauptverfasser: GREINER, J, SPENGLER, D. H, KRÜGER, J, TARIVERDIAN, G
Format: Artikel
Sprache:eng
Schlagworte:
ABO Blood-Group System
Amniotic Fluid - analysis
Biological and medical sciences
Diseases of striated muscles. Neuromuscular diseases
Female
Genetic Markers
Humans
Infant, Newborn
Medical sciences
Myotonic Dystrophy - diagnosis
Myotonic Dystrophy - genetics
Neurology
Pregnancy
Prenatal Diagnosis
Saliva - analysis
Urine - analysis
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Zusammenfassung:To verify the reliability of secretor status for prenatal diagnosis of myotonic dystrophy (DM), 179 amniotic fluid samples were compared with saliva or urine samples of the infants by hemagglutination inhibition. While no discrepancies were observed, problems could arise with intermediate results. Additionally, secretor typing is only informative in 8.4% of patients.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00291729