Identity-by-descent analysis of sibship configurations when parental haplotypes can be distinguished

Identity-by-descent analysis of sibship configurations when parental haplotypes can be distinguished

Haplotype sharing patterns of sibs identical‐by‐descent are examined following the method of Ethier and Hodge [1985] but taking account of which parent contributes the shared genes. A means of specification of all distinct sibship configurations is considered, along with the corresponding probabilit...

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Veröffentlicht in:American journal of medical genetics 1988-02, Vol.29 (2), p.425-429
Hauptverfasser: Shute, Nereda C. E., Optiz, John M., Reynolds, James F.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
disease-marker studies
General aspects. Genetic counseling
haplotype sharing patterns
Haplotypes
Humans
Medical genetics
Medical sciences
Models, Theoretical
Probability
rearrangements
Sibling Relations
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Zusammenfassung:Haplotype sharing patterns of sibs identical‐by‐descent are examined following the method of Ethier and Hodge [1985] but taking account of which parent contributes the shared genes. A means of specification of all distinct sibship configurations is considered, along with the corresponding probability of each configuration and the total number of configurations for differing sibship sizes.
ISSN:0148-7299
1096-8628
DOI:10.1002/ajmg.1320290226