Specific uptake of intracranial horseradish peroxidase (HRP) by microglial cells in the goldfish
Intracranial injections of horseradish peroxidase (HRP) in the goldfish labeled a population of cells with many similarities to microglia. The fact that neither macroglia nor neurons appeared to be labeled by these injections supports this identification. The labeled cells responded to Wallerian deg...
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| Veröffentlicht in: | Neuroscience letters 1996-04, Vol.208 (1), p.13-16 |
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| container_title | Neuroscience letters |
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| creator | Moorhouse, L. Pederson, K. Levine, R.L. |
| description | Intracranial injections of horseradish peroxidase (HRP) in the goldfish labeled a population of cells with many similarities to microglia. The fact that neither macroglia nor neurons appeared to be labeled by these injections supports this identification. The labeled cells responded to Wallerian degeneration of the optic paths by accumulating in the optic terminal zones, a cellular behavior which strongly supports their identification as microglia. |
| doi_str_mv | 10.1016/0304-3940(96)12540-4 |
| format | Article |
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The fact that neither macroglia nor neurons appeared to be labeled by these injections supports this identification. The labeled cells responded to Wallerian degeneration of the optic paths by accumulating in the optic terminal zones, a cellular behavior which strongly supports their identification as microglia.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - cytology</subject><subject>Brain - metabolism</subject><subject>Carassius auratus</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Goldfish - metabolism</subject><subject>Horseradish Peroxidase - metabolism</subject><subject>Horseradish peroxidase uptake</subject><subject>Immunohistochemistry</subject><subject>Isolated neuron and nerve. Neuroglia</subject><subject>Microglia - metabolism</subject><subject>Microglial activation</subject><subject>Neuroglia - metabolism</subject><subject>Neurons - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><subject>Wallerian degeneration</subject><subject>Wallerian Degeneration - physiology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P4zAQhq0VCArLP1gkHxCCQ1h_27mstKr4kpBAu9yN40yoIW2CnSL49zi06hFOc5jnHc08g9AvSs4ooeo34UQUvBTkpFSnlElBCvEDTajRrNClZltoskF20V5KT4QQSaXYQTtGc0oVn6CH_z340ASPl_3gngF3DQ6LITof3SK4Fs-6mCC6OqQZ7iF2b6F2CfDJ1b-7U1y943nwsXtsR9RD26acxsMM8GPX1k0O_UTbjWsTHKzrPrq_OL-fXhU3t5fX0783hRdUD4UkNaFgnGBKaM8Yd6bUpXQ-H1Y1lNTAKm4842A8MMmrsqqY9A2X2mlO-D46Xo3tY_eyhDTYeUjjQm4B3TJZbahSSupvQSqNNEKLDIoVmO9LKUJj-xjmLr5bSuz4ADvataNdWyr7-QA7xg7X85fVHOpNaG0894_WfZe8a5us2Ye0wThRpZQsY39WGGRnrwGiTT7AwkMdIvjB1l34eo8Puf2gwg</recordid><startdate>19960412</startdate><enddate>19960412</enddate><creator>Moorhouse, L.</creator><creator>Pederson, K.</creator><creator>Levine, R.L.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>F1W</scope><scope>H95</scope><scope>L.G</scope><scope>7X8</scope></search><sort><creationdate>19960412</creationdate><title>Specific uptake of intracranial horseradish peroxidase (HRP) by microglial cells in the goldfish</title><author>Moorhouse, L. ; Pederson, K. ; Levine, R.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-50d01e8a42647c223a89795ac125bf10de2b38c23e8ce253b9bb25cf357a7303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - cytology</topic><topic>Brain - metabolism</topic><topic>Carassius auratus</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Goldfish - metabolism</topic><topic>Horseradish Peroxidase - metabolism</topic><topic>Horseradish peroxidase uptake</topic><topic>Immunohistochemistry</topic><topic>Isolated neuron and nerve. Neuroglia</topic><topic>Microglia - metabolism</topic><topic>Microglial activation</topic><topic>Neuroglia - metabolism</topic><topic>Neurons - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><topic>Wallerian degeneration</topic><topic>Wallerian Degeneration - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moorhouse, L.</creatorcontrib><creatorcontrib>Pederson, K.</creatorcontrib><creatorcontrib>Levine, R.L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moorhouse, L.</au><au>Pederson, K.</au><au>Levine, R.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Specific uptake of intracranial horseradish peroxidase (HRP) by microglial cells in the goldfish</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1996-04-12</date><risdate>1996</risdate><volume>208</volume><issue>1</issue><spage>13</spage><epage>16</epage><pages>13-16</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Intracranial injections of horseradish peroxidase (HRP) in the goldfish labeled a population of cells with many similarities to microglia. 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| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1996-04, Vol.208 (1), p.13-16 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78166657 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Brain - cytology Brain - metabolism Carassius auratus Freshwater Fundamental and applied biological sciences. Psychology Goldfish - metabolism Horseradish Peroxidase - metabolism Horseradish peroxidase uptake Immunohistochemistry Isolated neuron and nerve. Neuroglia Microglia - metabolism Microglial activation Neuroglia - metabolism Neurons - metabolism Vertebrates: nervous system and sense organs Wallerian degeneration Wallerian Degeneration - physiology |
| title | Specific uptake of intracranial horseradish peroxidase (HRP) by microglial cells in the goldfish |
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