Specific uptake of intracranial horseradish peroxidase (HRP) by microglial cells in the goldfish

Intracranial injections of horseradish peroxidase (HRP) in the goldfish labeled a population of cells with many similarities to microglia. The fact that neither macroglia nor neurons appeared to be labeled by these injections supports this identification. The labeled cells responded to Wallerian deg...

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Veröffentlicht in:	Neuroscience letters 1996-04, Vol.208 (1), p.13-16
Hauptverfasser:	Moorhouse, L., Pederson, K., Levine, R.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain - cytology Brain - metabolism Carassius auratus Freshwater Fundamental and applied biological sciences. Psychology Goldfish - metabolism Horseradish Peroxidase - metabolism Horseradish peroxidase uptake Immunohistochemistry Isolated neuron and nerve. Neuroglia Microglia - metabolism Microglial activation Neuroglia - metabolism Neurons - metabolism Vertebrates: nervous system and sense organs Wallerian degeneration Wallerian Degeneration - physiology
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Zusammenfassung:	Intracranial injections of horseradish peroxidase (HRP) in the goldfish labeled a population of cells with many similarities to microglia. The fact that neither macroglia nor neurons appeared to be labeled by these injections supports this identification. The labeled cells responded to Wallerian degeneration of the optic paths by accumulating in the optic terminal zones, a cellular behavior which strongly supports their identification as microglia.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(96)12540-4