Polymerized serum albumin beads possessing slow release properties for use in vaccines
Experimental vaccines have been made by co-polymerizing virus particles and virus subunits into rabbit serum albumin beads. When injected into rabbits these model vaccines induced specific humoral antibody production and mimicked vaccines prepared using Freund's incomplete adjuvant. No adverse...
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| Veröffentlicht in: | Vaccine 1988-02, Vol.6 (1), p.33-38 |
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| container_end_page | 38 |
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| container_title | Vaccine |
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| creator | Martin, M.E.D. Dewar, J.B. Newman, J.F.E. |
| description | Experimental vaccines have been made by co-polymerizing virus particles and virus subunits into rabbit serum albumin beads. When injected into rabbits these model vaccines induced specific humoral antibody production and mimicked vaccines prepared using Freund's incomplete adjuvant. No adverse reactions occurred in experimental rabbits and no antibodies reacting with polymerized rabbit serum albumin beads were found. Immunostimulation is attributed to a slow release of antigen coinciding with the gradual breakdown of bead structure. |
| doi_str_mv | 10.1016/0264-410X(88)90011-4 |
| format | Article |
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Psychology ; Glutaral - immunology ; Immunization ; Immunoglobulin G - analysis ; Mice ; Microbiology ; Microspheres ; Nodamura virus ; polymerized protein ; Polymers ; Rabbits ; Radioimmunoassay ; Serum Albumin - analysis ; Serum Albumin - immunology ; slow release ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Viral Proteins - immunology ; Viral Vaccines - administration & dosage ; Viral Vaccines - immunology ; Virology</subject><ispartof>Vaccine, 1988-02, Vol.6 (1), p.33-38</ispartof><rights>1988</rights><rights>1989 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-d52d419c1c82e15a35254dd8b86b2b0da758202fdafb9383614d33ddec9e7ca33</citedby><cites>FETCH-LOGICAL-c417t-d52d419c1c82e15a35254dd8b86b2b0da758202fdafb9383614d33ddec9e7ca33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0264-410X(88)90011-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6984325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3128017$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martin, M.E.D.</creatorcontrib><creatorcontrib>Dewar, J.B.</creatorcontrib><creatorcontrib>Newman, J.F.E.</creatorcontrib><title>Polymerized serum albumin beads possessing slow release properties for use in vaccines</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Experimental vaccines have been made by co-polymerizing virus particles and virus subunits into rabbit serum albumin beads. When injected into rabbits these model vaccines induced specific humoral antibody production and mimicked vaccines prepared using Freund's incomplete adjuvant. No adverse reactions occurred in experimental rabbits and no antibodies reacting with polymerized rabbit serum albumin beads were found. Immunostimulation is attributed to a slow release of antigen coinciding with the gradual breakdown of bead structure.</description><subject>Adjuvant</subject><subject>Animals</subject><subject>Animals, Suckling - immunology</subject><subject>beads</subject><subject>Biological and medical sciences</subject><subject>Cross-Linking Reagents</subject><subject>Delayed-Action Preparations</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutaral - immunology</subject><subject>Immunization</subject><subject>Immunoglobulin G - analysis</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Microspheres</subject><subject>Nodamura virus</subject><subject>polymerized protein</subject><subject>Polymers</subject><subject>Rabbits</subject><subject>Radioimmunoassay</subject><subject>Serum Albumin - analysis</subject><subject>Serum Albumin - immunology</subject><subject>slow release</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Viral Proteins - immunology</subject><subject>Viral Vaccines - administration & dosage</subject><subject>Viral Vaccines - immunology</subject><subject>Virology</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rFEEQhpugxE3MP1Dog0hyGO3qj5meS0CCSYSAOah4a3q6a6RlPtaunUjy6-11lz3qqaDqeYuqh7FXIN6BgPq9kLWuNIjv59ZetEIAVPqIrcA2qpIG7DO2OiAv2AnRTyGEUdAes2MF0gpoVuzb_Tw8jpjTE0ZOmJeR-6FbxjTxDn0kvp6JkChNPzgN82-ecUBPyNd5XmPeJCTez5kvpVUyDz6ENCG9ZM97PxCe7esp-3r98cvVbXX3-ebT1Ye7KmhoNlU0MmpoAwQrEYxXRhodo-1s3clORN8YK4Xso--7VllVg45KxYihxSZ4pU7Z293ecs6vBWnjxkQBh8FPOC_kGgvGtrL9Lwja6lo0ooB6B4ZcPs_Yu3VOo8-PDoTbendbqW4r1Vnr_np3usRe7_cv3YjxENqLLvM3-7mn4Ic--ykkOmB1a7WSpmCXOwyLtIeE2VFIOAWMKWPYuDinf9_xBzdWn6g</recordid><startdate>19880201</startdate><enddate>19880201</enddate><creator>Martin, M.E.D.</creator><creator>Dewar, J.B.</creator><creator>Newman, J.F.E.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19880201</creationdate><title>Polymerized serum albumin beads possessing slow release properties for use in vaccines</title><author>Martin, M.E.D. ; Dewar, J.B. ; Newman, J.F.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-d52d419c1c82e15a35254dd8b86b2b0da758202fdafb9383614d33ddec9e7ca33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adjuvant</topic><topic>Animals</topic><topic>Animals, Suckling - immunology</topic><topic>beads</topic><topic>Biological and medical sciences</topic><topic>Cross-Linking Reagents</topic><topic>Delayed-Action Preparations</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutaral - immunology</topic><topic>Immunization</topic><topic>Immunoglobulin G - analysis</topic><topic>Mice</topic><topic>Microbiology</topic><topic>Microspheres</topic><topic>Nodamura virus</topic><topic>polymerized protein</topic><topic>Polymers</topic><topic>Rabbits</topic><topic>Radioimmunoassay</topic><topic>Serum Albumin - analysis</topic><topic>Serum Albumin - immunology</topic><topic>slow release</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Viral Proteins - immunology</topic><topic>Viral Vaccines - administration & dosage</topic><topic>Viral Vaccines - immunology</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martin, M.E.D.</creatorcontrib><creatorcontrib>Dewar, J.B.</creatorcontrib><creatorcontrib>Newman, J.F.E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martin, M.E.D.</au><au>Dewar, J.B.</au><au>Newman, J.F.E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymerized serum albumin beads possessing slow release properties for use in vaccines</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>1988-02-01</date><risdate>1988</risdate><volume>6</volume><issue>1</issue><spage>33</spage><epage>38</epage><pages>33-38</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Experimental vaccines have been made by co-polymerizing virus particles and virus subunits into rabbit serum albumin beads. When injected into rabbits these model vaccines induced specific humoral antibody production and mimicked vaccines prepared using Freund's incomplete adjuvant. No adverse reactions occurred in experimental rabbits and no antibodies reacting with polymerized rabbit serum albumin beads were found. Immunostimulation is attributed to a slow release of antigen coinciding with the gradual breakdown of bead structure.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>3128017</pmid><doi>10.1016/0264-410X(88)90011-4</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 1988-02, Vol.6 (1), p.33-38 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78158929 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adjuvant Animals Animals, Suckling - immunology beads Biological and medical sciences Cross-Linking Reagents Delayed-Action Preparations Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology Glutaral - immunology Immunization Immunoglobulin G - analysis Mice Microbiology Microspheres Nodamura virus polymerized protein Polymers Rabbits Radioimmunoassay Serum Albumin - analysis Serum Albumin - immunology slow release Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viral Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology Virology |
| title | Polymerized serum albumin beads possessing slow release properties for use in vaccines |
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