Polymerized serum albumin beads possessing slow release properties for use in vaccines

Experimental vaccines have been made by co-polymerizing virus particles and virus subunits into rabbit serum albumin beads. When injected into rabbits these model vaccines induced specific humoral antibody production and mimicked vaccines prepared using Freund's incomplete adjuvant. No adverse...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 1988-02, Vol.6 (1), p.33-38
Hauptverfasser:	Martin, M.E.D., Dewar, J.B., Newman, J.F.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant Animals Animals, Suckling - immunology beads Biological and medical sciences Cross-Linking Reagents Delayed-Action Preparations Enzyme-Linked Immunosorbent Assay Female Fundamental and applied biological sciences. Psychology Glutaral - immunology Immunization Immunoglobulin G - analysis Mice Microbiology Microspheres Nodamura virus polymerized protein Polymers Rabbits Radioimmunoassay Serum Albumin - analysis Serum Albumin - immunology slow release Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viral Proteins - immunology Viral Vaccines - administration & dosage Viral Vaccines - immunology Virology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Experimental vaccines have been made by co-polymerizing virus particles and virus subunits into rabbit serum albumin beads. When injected into rabbits these model vaccines induced specific humoral antibody production and mimicked vaccines prepared using Freund's incomplete adjuvant. No adverse reactions occurred in experimental rabbits and no antibodies reacting with polymerized rabbit serum albumin beads were found. Immunostimulation is attributed to a slow release of antigen coinciding with the gradual breakdown of bead structure.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/0264-410X(88)90011-4