Ragweed Immunotherapy in Adult Asthma

To the Editor: Creticos et al. (Feb. 22 issue) 1 found that in adults with asthma exacerbated by seasonal exposure to ragweed, immunotherapy improved objective measures of asthma and allergy, but the clinical effects were limited, and many were not sustained over a period of two years. Their findings support the conclusions of our meta-analysis of randomized, controlled trials. 2 However, their failure to demonstrate a significant difference from base line in medication use and asthma symptoms in the second year requires critical analysis. Screening of volunteers resulted in a drop in the number of suitable subjects from 1000 to 127. One . . .