Growth hormone modulates IL-α and IFN-γ release by murine splenocytes activated by LPS or porins of Salmonella typhimurium

The effect of growth hormone (GH) on the release of IL-1alpha and IFN-gamma from murine splenocytes was investigated. Their release from splenocytes activated by Salmonella enterica serovar Typhimurium lipopolysaccharide (LPS) 0.5 microg/ml was increased by c. 65% in the presence of GH 100 pg/ml. Wi...

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Veröffentlicht in:	Journal of medical microbiology 1996-07, Vol.45 (1), p.40-47
Hauptverfasser:	SOMMESE, L, DONNARUMMA, G, CIPOLLARO DE L'ERO, G, MARCATILI, A, VITIELLO, M, GALDIERO, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Biological and medical sciences Electrophoresis, Polyacrylamide Gel Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Growth Hormone - pharmacology Immunobiology Interferon-gamma - genetics Interferon-gamma - metabolism Interleukin-1 - genetics Interleukin-1 - metabolism Lipopolysaccharides - chemistry Lipopolysaccharides - pharmacology Lymphocyte Activation - drug effects Male Mice Mice, Inbred BALB C Modulation of the immune response (stimulation, suppression) Polymerase Chain Reaction Polymyxins - pharmacology Porins - chemistry Porins - pharmacology RNA, Messenger - biosynthesis Salmonella typhimurium Salmonella typhimurium - immunology Spleen - cytology Spleen - drug effects Spleen - immunology Swine
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Zusammenfassung:	The effect of growth hormone (GH) on the release of IL-1alpha and IFN-gamma from murine splenocytes was investigated. Their release from splenocytes activated by Salmonella enterica serovar Typhimurium lipopolysaccharide (LPS) 0.5 microg/ml was increased by c. 65% in the presence of GH 100 pg/ml. With splenocytes activated by S. Typhimurium porins 5 microg/ml, GH increased the production of both IL-1alpha and IFN-gamma by c. 56%. Polymyxin treatment abolished the cytokine-releasing activity of LPS but had no effect on the activity of the porin preparation.
ISSN:	0022-2615 1473-5644
DOI:	10.1099/00222615-45-1-40