Effects of biotin deficiency on serum fatty acid composition: evidence for abnormalities in humans

A study determined fatty acid profiles in serum phospholipids, cholesteryl esters, triglycerides, and free fatty acids in 3 patients who developed a biotin deficiency while on parenteral feeding. The results indicated that odd-chain fatty acid levels were increased in each of the 4 lipid classes exa...

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Veröffentlicht in:	The Journal of nutrition 1988-03, Vol.118 (3), p.342-348
Hauptverfasser:	Mock, D.M, Johnson, S.B, Holman, R.T
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl-CoA Carboxylase - deficiency Biological and medical sciences biotin Biotin - administration & dosage Biotin - deficiency blood composition Cholesterol Esters - blood fatty acids Fatty Acids - blood Fatty Acids, Nonesterified - blood Female Humans Infant Male Medical sciences Metabolic diseases nutrient-nutrient interactions nutrition research Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...) Phospholipids - blood Triglycerides - blood vitamin deficiencies
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Beschreibung
Zusammenfassung:	A study determined fatty acid profiles in serum phospholipids, cholesteryl esters, triglycerides, and free fatty acids in 3 patients who developed a biotin deficiency while on parenteral feeding. The results indicated that odd-chain fatty acid levels were increased in each of the 4 lipid classes examined. This was corrected by biotin supplementation. A possible mechanism for this effect is discussed.(wz)
ISSN:	0022-3166 1541-6100
DOI:	10.1093/jn/118.3.342