Cyclic AMP inhibits expression of D-type cyclins and cdk4 and induces p27Kip1 in G-CSF-treated NFS-60 cells

The addition of cAMP inhibits G-CSF-mediated proliferation and suppresses pRB phosphorylation in NFS-60 cells. We show that the latter could be attributed to different effects of cAMP in these cells: (i) down-regulation of the levels of cyclins D2 and D3, and cdk4, and (ii) induction of the p27Kip1...

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Veröffentlicht in:	Biochemical and biophysical research communications 1996-07, Vol.224 (1), p.10-16
Hauptverfasser:	Ward, A C, Csar, X F, Hoffmann, B W, Hamilton, J A
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-3-isobutylxanthine - pharmacology 8-Bromo Cyclic Adenosine Monophosphate - analogs & derivatives 8-Bromo Cyclic Adenosine Monophosphate - pharmacology Animals Blotting, Northern Cell Cycle Proteins Cell Division - drug effects Cell Line Cyclic AMP - analogs & derivatives Cyclic AMP - pharmacology Cyclin D Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinase Inhibitor p27 Cyclin-Dependent Kinases - biosynthesis Cyclins - biosynthesis Dinoprostone - pharmacology DNA - biosynthesis Dose-Response Relationship, Drug Genes, Tumor Suppressor Granulocyte Colony-Stimulating Factor - pharmacology Kinetics Microtubule-Associated Proteins - biosynthesis Phosphorylation Proto-Oncogene Proteins Tumor Suppressor Proteins
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Zusammenfassung:	The addition of cAMP inhibits G-CSF-mediated proliferation and suppresses pRB phosphorylation in NFS-60 cells. We show that the latter could be attributed to different effects of cAMP in these cells: (i) down-regulation of the levels of cyclins D2 and D3, and cdk4, and (ii) induction of the p27Kip1 inhibitor of cdk4.
ISSN:	0006-291X