Endothelin Receptor Antagonist Triterpenoid, Myriceric Acid A, Isolated from Myrica cerifera, and Structure Activity Relationships of Its Derivatives

As the first non-peptide endothelin receptor antagonist form a higher plant, a new triter penoid, myiceric acid A (50-235) (1) was isolated from the bayberry, Myrica cerifera. myriceric acid A (1) inhibited not only an endothelin-1-induced increase in cytosolic free Ca 2+> concentration (IC50=11±...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1996/02/15, Vol.44(2), pp.343-351
Hauptverfasser:	SAKURAWI, Kensuke, YASUDA, Fumio, TOZYO, Takehiko, NAKAMURA, Miharu, SATO, Tomohiro, KIKUCHI, Junko, TERUI, Yoshihiro, IKENISHI, Yuji, IWATA, Tsuyoshi, TAKAHASHI, Kazuhiro, KONOIKE, Toshiro, MIHARA, Shin-ichi, FUJIMOTO, Masafumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium - metabolism Cells, Cultured Cytosol - drug effects Cytosol - metabolism endothelin receptor antagonist Endothelin Receptor Antagonists General pharmacology Magnetic Resonance Spectroscopy Medical sciences Molecular Conformation Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Myrica cerifera myriceric acid A myricerica acid D myricericc acid C Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Rats Structure-Activity Relationship triterpene Triterpenes - isolation & purification Triterpenes - pharmacology
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Zusammenfassung:	As the first non-peptide endothelin receptor antagonist form a higher plant, a new triter penoid, myiceric acid A (50-235) (1) was isolated from the bayberry, Myrica cerifera. myriceric acid A (1) inhibited not only an endothelin-1-induced increase in cytosolic free Ca 2+> concentration (IC50=11±2nM) but [
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.44.343