Pathological and immunological observations on tropical spastic paraparesis in patients from jamaica

The neuropathological examination of the spinal cord of 2 Jamaican patients with classical tropical spastic paraparesis disclosed an intense chronic meningomyelitis with demyelination. In the 1 case in which serum and cerebrospinal fluid were available, antibodies to the human T‐lymphotropic virus t...

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Veröffentlicht in:	Annals of neurology 1988, Vol.23 (S1), p.S156-S160
Hauptverfasser:	Piccardo, Pedro, Ceroni, Mauro, Rodgers-Johnson, Pamela, Mora, Carlos, Asher, David M., Char, Guendra, Gibbs Jr, Clarence J., Gajdusek, D. Carleton
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Anti-Idiotypic - analysis Antibodies, Anti-Idiotypic - cerebrospinal fluid Antibodies, Viral - analysis Antibodies, Viral - cerebrospinal fluid Brain - pathology Deltaretrovirus Antibodies Female Humans Immunoglobulin G - immunology Jamaica Muscle Spasticity - immunology Muscle Spasticity - pathology Paraplegia - immunology Paraplegia - pathology Spinal Cord - pathology Tropical Medicine
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Zusammenfassung:	The neuropathological examination of the spinal cord of 2 Jamaican patients with classical tropical spastic paraparesis disclosed an intense chronic meningomyelitis with demyelination. In the 1 case in which serum and cerebrospinal fluid were available, antibodies to the human T‐lymphotropic virus type 1 were found.
ISSN:	0364-5134 1531-8249
DOI:	10.1002/ana.410230735