Synthesis and Modification of a Novel 1β-Methyl Carbapenem Antibiotic, S-4661

We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of antibiotics 1996/05/25, Vol.49(5), pp.478-484
Hauptverfasser:	ISO, YASUYOSHI, IRIE, TADASHI, IWAKI, TSUTOMU, KII, MAKOTO, SENDO, YUJI, MOTOKAWA, KIYOSHI, NISHITANI, YASUHIRO
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Carbapenems - chemical synthesis Carbapenems - chemistry Carbapenems - pharmacology Doripenem Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Stereoisomerism Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	We describe an efficient method for introducing a sulfamoylamino group into the C-2' position of pyrrolidine using the Mitsunobu reaction. S-4661, its N-methyl analogues and stereoisomers were synthesized using this method and their structure-activity relationships were investigated.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.49.478