Comparison of arterialized venous with arterial blood propofol concentrations during sub-anaesthetic infusions in volunteers
We have compared propofol concentrations in arterial and arterialized venous blood (from the radial artery at the wrist and a vein in the opposite forearm) in five volunteers during a sub-anaesthetic increasing infusion regimen designed to produce pseudo-steady-state arterial concentrations of 0.06,...
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Veröffentlicht in: | British journal of anaesthesia : BJA 1996-03, Vol.76 (3), p.401-404 |
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Sprache: | eng |
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Zusammenfassung: | We have compared propofol concentrations in arterial and arterialized venous blood (from the radial artery at the wrist and a vein in the opposite forearm) in five volunteers during a sub-anaesthetic increasing infusion regimen designed to produce pseudo-steady-state arterial concentrations of 0.06, 0.17 and 0.43 micrograms ml-1. As in a previous study, we found no statistically significant difference between sampling sites (P = 0.66). However, changes in the method of arterialization yielded a reduction in the observed variability, with the arterialized venous propofol concentration lying within +/- 23% (95% reference interval) of the corresponding arterial concentration compared with 1 +/- 43%, as reported previously. |
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ISSN: | 0007-0912 1471-6771 |
DOI: | 10.1093/bja/76.3.401 |