Coexpression of p53 and c-erbB-2 proteins is associated with histological type, tumour stage, and cell proliferation in malignant salivary gland tumours

The development and progression of cancer are known to be regulated by various oncogenes and tumour suppressor genes. We analysed 63 primary malignant salivary gland tumours for the expression of p53 and c-erbB-2 proteins. Immunohistochemically, 7 of 63 tumours (11%) showed diffuse nuclear staining...

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Veröffentlicht in:	Virchows Archiv : an international journal of pathology 1996-05, Vol.428 (2), p.75-83
1. Verfasser:	KAMIO, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - immunology Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Aged Antigens, Neoplasm - analysis Biological and medical sciences Carcinoma - immunology Carcinoma - metabolism Carcinoma - pathology Cell Division Female Humans Ki-67 Antigen - analysis Male Medical sciences Middle Aged Neoplasm Proteins - metabolism Neoplasm Staging Otorhinolaryngology. Stomatology Prognosis Proto-Oncogene Proteins - metabolism Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-3 Salivary Gland Neoplasms - immunology Salivary Gland Neoplasms - metabolism Salivary Gland Neoplasms - pathology Tumor Suppressor Protein p53 - metabolism Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Beschreibung
Zusammenfassung:	The development and progression of cancer are known to be regulated by various oncogenes and tumour suppressor genes. We analysed 63 primary malignant salivary gland tumours for the expression of p53 and c-erbB-2 proteins. Immunohistochemically, 7 of 63 tumours (11%) showed diffuse nuclear staining for p53 protein, and all 7 were also positive for c-erbB-2 protein. The overexpression of p53 protein correlated closely with the overexpression of c-erbB-2 protein (P
ISSN:	0945-6317 1432-2307
DOI:	10.1007/BF00193934