Insulin action on brain microvessels; Effect on alkaline phosphatase
The effects of insulin on brain alkaline phosphatase activity have been examined. Insulin inhibited the activity of alkaline phosphatase on brain microvessels in in vitro experiments. The inhibition observed was of the non-competitive type. These observations indicate that the hormone is able to ind...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1988-01, Vol.150 (2), p.583-590 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Catalán, R.E. Martínez, A.M. Aragonés, M.D. Miguel, B.G. Robles, A. |
| description | The effects of insulin on brain alkaline phosphatase activity have been examined. Insulin inhibited the activity of alkaline phosphatase on brain microvessels in in vitro experiments. The inhibition observed was of the non-competitive type. These observations indicate that the hormone is able to induce neurochemical modifications revealed in this case as changes in the phosphate transfer enzymes in brain microvessels. |
| doi_str_mv | 10.1016/0006-291X(88)90433-0 |
| format | Article |
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Insulin inhibited the activity of alkaline phosphatase on brain microvessels in in vitro experiments. The inhibition observed was of the non-competitive type. These observations indicate that the hormone is able to induce neurochemical modifications revealed in this case as changes in the phosphate transfer enzymes in brain microvessels.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/0006-291X(88)90433-0</identifier><identifier>PMID: 3277629</identifier><identifier>CODEN: BBRCA9</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>ACTIVIDAD ENZIMATICA ; ACTIVITE ENZYMATIQUE ; ALKALINE PHOSPHATASE ; Alkaline Phosphatase - metabolism ; ANATOMIA ANIMAL ; ANATOMIE ANIMALE ; ANIMAL ANATOMY ; ANIMAL PHYSIOLOGY ; Animals ; Biological and medical sciences ; BLOOD VESSELS ; BOVIN ; BRAIN ; Capillaries - drug effects ; Capillaries - enzymology ; CATTLE ; Cell physiology ; Cerebral Cortex - blood supply ; CEREBRO ; Cerebrovascular Circulation ; ENCEPHALE ; ENZYMIC ACTIVITY ; FISIOLOGIA ANIMAL ; FOSFATASA ALCALINA ; Fundamental and applied biological sciences. Psychology ; GANADO BOVINO ; Hormonal regulation ; INSULIN ; Insulin - pharmacology ; INSULINA ; INSULINE ; Kinetics ; Microcirculation - enzymology ; Molecular and cellular biology ; NERVOUS SYSTEM ; PHOSPHATASE ALCALINE ; PHYSIOLOGIE ANIMALE ; SISTEMA NERVIOSO ; SYSTEME NERVEUX ; VAISSEAU SANGUIN ; VASOS SANGUINEOS</subject><ispartof>Biochemical and biophysical research communications, 1988-01, Vol.150 (2), p.583-590</ispartof><rights>1988</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-be57d4763708962773c9956e524fbd13522b152ae61128a319b6a37d0063cf4d3</citedby><cites>FETCH-LOGICAL-c439t-be57d4763708962773c9956e524fbd13522b152ae61128a319b6a37d0063cf4d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-291X(88)90433-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19556152$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3277629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Catalán, R.E.</creatorcontrib><creatorcontrib>Martínez, A.M.</creatorcontrib><creatorcontrib>Aragonés, M.D.</creatorcontrib><creatorcontrib>Miguel, B.G.</creatorcontrib><creatorcontrib>Robles, A.</creatorcontrib><title>Insulin action on brain microvessels; Effect on alkaline phosphatase</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>The effects of insulin on brain alkaline phosphatase activity have been examined. Insulin inhibited the activity of alkaline phosphatase on brain microvessels in in vitro experiments. The inhibition observed was of the non-competitive type. These observations indicate that the hormone is able to induce neurochemical modifications revealed in this case as changes in the phosphate transfer enzymes in brain microvessels.</description><subject>ACTIVIDAD ENZIMATICA</subject><subject>ACTIVITE ENZYMATIQUE</subject><subject>ALKALINE PHOSPHATASE</subject><subject>Alkaline Phosphatase - metabolism</subject><subject>ANATOMIA ANIMAL</subject><subject>ANATOMIE ANIMALE</subject><subject>ANIMAL ANATOMY</subject><subject>ANIMAL PHYSIOLOGY</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BLOOD VESSELS</subject><subject>BOVIN</subject><subject>BRAIN</subject><subject>Capillaries - drug effects</subject><subject>Capillaries - enzymology</subject><subject>CATTLE</subject><subject>Cell physiology</subject><subject>Cerebral Cortex - blood supply</subject><subject>CEREBRO</subject><subject>Cerebrovascular Circulation</subject><subject>ENCEPHALE</subject><subject>ENZYMIC ACTIVITY</subject><subject>FISIOLOGIA ANIMAL</subject><subject>FOSFATASA ALCALINA</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GANADO BOVINO</subject><subject>Hormonal regulation</subject><subject>INSULIN</subject><subject>Insulin - pharmacology</subject><subject>INSULINA</subject><subject>INSULINE</subject><subject>Kinetics</subject><subject>Microcirculation - enzymology</subject><subject>Molecular and cellular biology</subject><subject>NERVOUS SYSTEM</subject><subject>PHOSPHATASE ALCALINE</subject><subject>PHYSIOLOGIE ANIMALE</subject><subject>SISTEMA NERVIOSO</subject><subject>SYSTEME NERVEUX</subject><subject>VAISSEAU SANGUIN</subject><subject>VASOS SANGUINEOS</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkd9LHDEQx4O02Kvtf2DhXlrsw9qZJJsfCEKxWgXBBxX6FrLZWU27t3sme4L_vbneoW8tBIbw_cww3-8wto9wiIDqGwCoilv8dWDMVwtSiAp22AzBQsUR5Bs2e0Hesfc5_wZAlMrusl3BtVbcztiPiyGv-jjMfZjiOMzLa5Iv_0UMaXyknKnPR_PTrqMwrVXf__GFp_nyfszLez_5TB_Y2873mT5u6x67PTu9OTmvLq9-Xpx8v6yCFHaqGqp1K7USGoxVZQMRrK0V1Vx2TYui5rzBmntSiNx4gbZRXui2mBChk63YY182c5dpfFhRntwi5kB97wcaV9lpg6Al2P-CWIMwqGQB5QYsZnNO1LlligufnhyCW6fs1hG6dYTOGPc3ZQel7dN2_qpZUPvStI216J-3us_B913yQ4j5dbata1WcFm5_w3V-dP4uFeb22hiujVbGFPl4I5cb0GOk5HKINARqYyrncO0Y_73nM5E4n6E</recordid><startdate>19880129</startdate><enddate>19880129</enddate><creator>Catalán, R.E.</creator><creator>Martínez, A.M.</creator><creator>Aragonés, M.D.</creator><creator>Miguel, B.G.</creator><creator>Robles, A.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19880129</creationdate><title>Insulin action on brain microvessels; Effect on alkaline phosphatase</title><author>Catalán, R.E. ; Martínez, A.M. ; Aragonés, M.D. ; Miguel, B.G. ; Robles, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-be57d4763708962773c9956e524fbd13522b152ae61128a319b6a37d0063cf4d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>ACTIVIDAD ENZIMATICA</topic><topic>ACTIVITE ENZYMATIQUE</topic><topic>ALKALINE PHOSPHATASE</topic><topic>Alkaline Phosphatase - metabolism</topic><topic>ANATOMIA ANIMAL</topic><topic>ANATOMIE ANIMALE</topic><topic>ANIMAL ANATOMY</topic><topic>ANIMAL PHYSIOLOGY</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>BLOOD VESSELS</topic><topic>BOVIN</topic><topic>BRAIN</topic><topic>Capillaries - drug effects</topic><topic>Capillaries - enzymology</topic><topic>CATTLE</topic><topic>Cell physiology</topic><topic>Cerebral Cortex - blood supply</topic><topic>CEREBRO</topic><topic>Cerebrovascular Circulation</topic><topic>ENCEPHALE</topic><topic>ENZYMIC ACTIVITY</topic><topic>FISIOLOGIA ANIMAL</topic><topic>FOSFATASA ALCALINA</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GANADO BOVINO</topic><topic>Hormonal regulation</topic><topic>INSULIN</topic><topic>Insulin - pharmacology</topic><topic>INSULINA</topic><topic>INSULINE</topic><topic>Kinetics</topic><topic>Microcirculation - enzymology</topic><topic>Molecular and cellular biology</topic><topic>NERVOUS SYSTEM</topic><topic>PHOSPHATASE ALCALINE</topic><topic>PHYSIOLOGIE ANIMALE</topic><topic>SISTEMA NERVIOSO</topic><topic>SYSTEME NERVEUX</topic><topic>VAISSEAU SANGUIN</topic><topic>VASOS SANGUINEOS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Catalán, R.E.</creatorcontrib><creatorcontrib>Martínez, A.M.</creatorcontrib><creatorcontrib>Aragonés, M.D.</creatorcontrib><creatorcontrib>Miguel, B.G.</creatorcontrib><creatorcontrib>Robles, A.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Catalán, R.E.</au><au>Martínez, A.M.</au><au>Aragonés, M.D.</au><au>Miguel, B.G.</au><au>Robles, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin action on brain microvessels; Effect on alkaline phosphatase</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1988-01-29</date><risdate>1988</risdate><volume>150</volume><issue>2</issue><spage>583</spage><epage>590</epage><pages>583-590</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>The effects of insulin on brain alkaline phosphatase activity have been examined. Insulin inhibited the activity of alkaline phosphatase on brain microvessels in in vitro experiments. The inhibition observed was of the non-competitive type. These observations indicate that the hormone is able to induce neurochemical modifications revealed in this case as changes in the phosphate transfer enzymes in brain microvessels.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>3277629</pmid><doi>10.1016/0006-291X(88)90433-0</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1988-01, Vol.150 (2), p.583-590 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE ALKALINE PHOSPHATASE Alkaline Phosphatase - metabolism ANATOMIA ANIMAL ANATOMIE ANIMALE ANIMAL ANATOMY ANIMAL PHYSIOLOGY Animals Biological and medical sciences BLOOD VESSELS BOVIN BRAIN Capillaries - drug effects Capillaries - enzymology CATTLE Cell physiology Cerebral Cortex - blood supply CEREBRO Cerebrovascular Circulation ENCEPHALE ENZYMIC ACTIVITY FISIOLOGIA ANIMAL FOSFATASA ALCALINA Fundamental and applied biological sciences. Psychology GANADO BOVINO Hormonal regulation INSULIN Insulin - pharmacology INSULINA INSULINE Kinetics Microcirculation - enzymology Molecular and cellular biology NERVOUS SYSTEM PHOSPHATASE ALCALINE PHYSIOLOGIE ANIMALE SISTEMA NERVIOSO SYSTEME NERVEUX VAISSEAU SANGUIN VASOS SANGUINEOS |
| title | Insulin action on brain microvessels; Effect on alkaline phosphatase |
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