Insulin action on brain microvessels; Effect on alkaline phosphatase

Insulin action on brain microvessels; Effect on alkaline phosphatase

The effects of insulin on brain alkaline phosphatase activity have been examined. Insulin inhibited the activity of alkaline phosphatase on brain microvessels in in vitro experiments. The inhibition observed was of the non-competitive type. These observations indicate that the hormone is able to ind...

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Veröffentlicht in:Biochemical and biophysical research communications 1988-01, Vol.150 (2), p.583-590
Hauptverfasser: Catalán, R.E., Martínez, A.M., Aragonés, M.D., Miguel, B.G., Robles, A.
Format: Artikel
Sprache:eng
Schlagworte:
ACTIVIDAD ENZIMATICA
ACTIVITE ENZYMATIQUE
ALKALINE PHOSPHATASE
Alkaline Phosphatase - metabolism
ANATOMIA ANIMAL
ANATOMIE ANIMALE
ANIMAL ANATOMY
ANIMAL PHYSIOLOGY
Animals
Biological and medical sciences
BLOOD VESSELS
BOVIN
BRAIN
Capillaries - drug effects
Capillaries - enzymology
CATTLE
Cell physiology
Cerebral Cortex - blood supply
CEREBRO
Cerebrovascular Circulation
ENCEPHALE
ENZYMIC ACTIVITY
FISIOLOGIA ANIMAL
FOSFATASA ALCALINA
Fundamental and applied biological sciences. Psychology
GANADO BOVINO
Hormonal regulation
INSULIN
Insulin - pharmacology
INSULINA
INSULINE
Kinetics
Microcirculation - enzymology
Molecular and cellular biology
NERVOUS SYSTEM
PHOSPHATASE ALCALINE
PHYSIOLOGIE ANIMALE
SISTEMA NERVIOSO
SYSTEME NERVEUX
VAISSEAU SANGUIN
VASOS SANGUINEOS
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Zusammenfassung:The effects of insulin on brain alkaline phosphatase activity have been examined. Insulin inhibited the activity of alkaline phosphatase on brain microvessels in in vitro experiments. The inhibition observed was of the non-competitive type. These observations indicate that the hormone is able to induce neurochemical modifications revealed in this case as changes in the phosphate transfer enzymes in brain microvessels.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(88)90433-0