Possible association of human growth hormone treatment with an occurrence of acute myeloblastic leukemia with an inversion of chromosome 3 in a child of pituitary dwarfism

An 11–yr‐old girl, who had been treated with human growth hormone (h‐GH) for 31 months, developed acute myeloblastic leukemia with an inv(3)(q21q26). Since CH has been suggested to influence the genesis of leukemia, and the inversion 3 has been reported only in adult leukemia patients, the GH treatm...

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Veröffentlicht in:	Medical and pediatric oncology 1988, Vol.16 (1), p.45-47
Hauptverfasser:	Endo, Machiko, Kaneko, Yasuhiko, Shikano, Takaaki, Minami, Hideki, Chino, Jun-Ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	abnormal karyotype acute nonlymphocytic leukemia Biological and medical sciences Child Chromosome Banding Chromosome Inversion Chromosomes, Human, Pair 3 Drug toxicity and drugs side effects treatment Dwarfism, Pituitary - drug therapy Female Growth Hormone - adverse effects Growth Hormone - therapeutic use Humans Leukemia, Myeloid, Acute - etiology Medical sciences Pharmacology. Drug treatments thyroxine Toxicity: blood
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Zusammenfassung:	An 11–yr‐old girl, who had been treated with human growth hormone (h‐GH) for 31 months, developed acute myeloblastic leukemia with an inv(3)(q21q26). Since CH has been suggested to influence the genesis of leukemia, and the inversion 3 has been reported only in adult leukemia patients, the GH treatment may have caused the development of leukemia or accelerated the proliferation of the leukemia cells.
ISSN:	0098-1532 1096-911X
DOI:	10.1002/mpo.2950160111