Regression after photorefractive keratectomy for myopia

Objective: To evaluate the effect of topical steroid treatment in eyes that showed refractive regression after photorefractive keratectomy (PRK) to correct myopia. Setting: Mater Private Hospital, Dublin, Republic of Ireland. Methods: In this prospective study with a minimum of 6 months follow-up, 289 eyes were treated over 2 ½ years. Of these eyes, 23 had myopic regression of 0.75 diopters (D) or more. Topical steroid treatment was given to reverse the regression. Refraction and uncorrected visual acuity before and after treatment were measured. Results: Twelve eyes in the regression group had at least 18 months of follow-up. At the final examination, eight of these eyes had an uncorrected visual acuity of 20/40 or better; six were within 1.00 D of intended refraction. Conclusion: Refractive regression after PRK for myopia was permanently reversed in some eyes; final stable refraction was close to the intended value in about half.