Effect of indapamide on an experimental model of cerebral ischemia in hypertensive rats
This study quantified the immediate general hemodynamic events following the bilateral carotid ligation-induced cerebral ischemia in normotensive and spontaneously hypertensive rats. The influence of treatment with indapamide was evaluated. In normotensive rats, hemodynamic values remained unchanged...
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| Veröffentlicht in: | The American journal of medicine 1988-01, Vol.84 (1), p.20-25 |
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| container_title | The American journal of medicine |
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| creator | Delbarre, Bernard Delbarre, Gisèle |
| description | This study quantified the immediate general hemodynamic events following the bilateral carotid ligation-induced cerebral ischemia in normotensive and spontaneously hypertensive rats. The influence of treatment with indapamide was evaluated. In normotensive rats, hemodynamic values remained unchanged during the 10 minutes following the carotid ligation. In spontaneously hypertensive rats, arterial pressure values immediately and significantly (p |
| doi_str_mv | 10.1016/0002-9343(88)90808-X |
| format | Article |
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The influence of treatment with indapamide was evaluated. In normotensive rats, hemodynamic values remained unchanged during the 10 minutes following the carotid ligation. In spontaneously hypertensive rats, arterial pressure values immediately and significantly (p <0.01) increased, up to 50 percent during the 10 minutes following the carotid ligation. Heart rate was unchanged. Indapamide at a short-term 3 mg/kg intraperitoneally, chosen in order to give a minimal (non-significant) antihypertensive effect in spontaneously hypertensive rats, significantly (p <0.01) reduced the bilateral carotid ligation-induced vasopressor response, whereas heart rate remained unchanged. The results presented here show that in spontaneously hypertensive rats, but not in normotensive rats, bilateral common carotid ligation induces an immediate and strong increase in arterial pressure values. These results compare with the previously described differences in cerebral ischemia-induced disorders in normotensive and hypertensive rats. Finally, indapamide, an antihypertensive agent that decreases vascular reactivity, significantly inhibits the carotid ligation-induced vasopressive response in hypertensive rats.</description><identifier>ISSN: 0002-9343</identifier><identifier>EISSN: 1555-7162</identifier><identifier>DOI: 10.1016/0002-9343(88)90808-X</identifier><identifier>PMID: 3341387</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Brain Ischemia - drug therapy ; Brain Ischemia - etiology ; Brain Ischemia - physiopathology ; Disease Models, Animal ; Diuretics - therapeutic use ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Hemodynamics - drug effects ; Hypertension - complications ; Hypertension - drug therapy ; Hypertension - physiopathology ; Indapamide - administration & dosage ; Indapamide - therapeutic use ; Injections, Intraperitoneal ; Male ; Rats ; Rats, Inbred SHR ; Rats, Inbred Strains ; Time Factors</subject><ispartof>The American journal of medicine, 1988-01, Vol.84 (1), p.20-25</ispartof><rights>1988</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2047-bcd5151ba6c83760405de0f7fdcefc66f4c2ed392058c35501edaf17f2e4be73</citedby><cites>FETCH-LOGICAL-c2047-bcd5151ba6c83760405de0f7fdcefc66f4c2ed392058c35501edaf17f2e4be73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9343(88)90808-X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3538,27906,27907,45977</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3341387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delbarre, Bernard</creatorcontrib><creatorcontrib>Delbarre, Gisèle</creatorcontrib><title>Effect of indapamide on an experimental model of cerebral ischemia in hypertensive rats</title><title>The American journal of medicine</title><addtitle>Am J Med</addtitle><description>This study quantified the immediate general hemodynamic events following the bilateral carotid ligation-induced cerebral ischemia in normotensive and spontaneously hypertensive rats. The influence of treatment with indapamide was evaluated. In normotensive rats, hemodynamic values remained unchanged during the 10 minutes following the carotid ligation. In spontaneously hypertensive rats, arterial pressure values immediately and significantly (p <0.01) increased, up to 50 percent during the 10 minutes following the carotid ligation. Heart rate was unchanged. Indapamide at a short-term 3 mg/kg intraperitoneally, chosen in order to give a minimal (non-significant) antihypertensive effect in spontaneously hypertensive rats, significantly (p <0.01) reduced the bilateral carotid ligation-induced vasopressor response, whereas heart rate remained unchanged. The results presented here show that in spontaneously hypertensive rats, but not in normotensive rats, bilateral common carotid ligation induces an immediate and strong increase in arterial pressure values. These results compare with the previously described differences in cerebral ischemia-induced disorders in normotensive and hypertensive rats. Finally, indapamide, an antihypertensive agent that decreases vascular reactivity, significantly inhibits the carotid ligation-induced vasopressive response in hypertensive rats.</description><subject>Animals</subject><subject>Brain Ischemia - drug therapy</subject><subject>Brain Ischemia - etiology</subject><subject>Brain Ischemia - physiopathology</subject><subject>Disease Models, Animal</subject><subject>Diuretics - therapeutic use</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Evaluation, Preclinical</subject><subject>Hemodynamics - drug effects</subject><subject>Hypertension - complications</subject><subject>Hypertension - drug therapy</subject><subject>Hypertension - physiopathology</subject><subject>Indapamide - administration & dosage</subject><subject>Indapamide - therapeutic use</subject><subject>Injections, Intraperitoneal</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred Strains</subject><subject>Time Factors</subject><issn>0002-9343</issn><issn>1555-7162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMotVb_gcKeRA-rk81mN3sRpNQPKHgp2FvIJhOM7EdNtsX-e1NbPHoKyTzvTOYh5JLCHQVa3ANAllYsZzdC3FYgQKTLIzKmnPO0pEV2TMZ_yCk5C-EzXqHixYiMGMspE-WYvM-sRT0kvU1cZ9RKtc5g0neJ6hL8XqF3LXaDapK2N9jsMI0eax9fXNAf2DoVg8nHNqIDdsFtMPFqCOfkxKom4MXhnJDF02wxfUnnb8-v08d5qjPIy7TWhlNOa1VowcoCcuAGwZbWaLS6KGyuMzSsyoALzTgHikZZWtoM8xpLNiHX-7Yr33-tMQyyjd_CplEd9usgSwGVoJBHMN-D2vcheLRyFVdTfispyJ1OuXMld66kEPJXp1zG2NWh_7pu0fyFDv5i_WFfx7jjxqGXQTvsNBrno1Zpevf_gB92fIVM</recordid><startdate>19880129</startdate><enddate>19880129</enddate><creator>Delbarre, Bernard</creator><creator>Delbarre, Gisèle</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19880129</creationdate><title>Effect of indapamide on an experimental model of cerebral ischemia in hypertensive rats</title><author>Delbarre, Bernard ; Delbarre, Gisèle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2047-bcd5151ba6c83760405de0f7fdcefc66f4c2ed392058c35501edaf17f2e4be73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Animals</topic><topic>Brain Ischemia - drug therapy</topic><topic>Brain Ischemia - etiology</topic><topic>Brain Ischemia - physiopathology</topic><topic>Disease Models, Animal</topic><topic>Diuretics - therapeutic use</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Evaluation, Preclinical</topic><topic>Hemodynamics - drug effects</topic><topic>Hypertension - complications</topic><topic>Hypertension - drug therapy</topic><topic>Hypertension - physiopathology</topic><topic>Indapamide - administration & dosage</topic><topic>Indapamide - therapeutic use</topic><topic>Injections, Intraperitoneal</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred Strains</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delbarre, Bernard</creatorcontrib><creatorcontrib>Delbarre, Gisèle</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delbarre, Bernard</au><au>Delbarre, Gisèle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of indapamide on an experimental model of cerebral ischemia in hypertensive rats</atitle><jtitle>The American journal of medicine</jtitle><addtitle>Am J Med</addtitle><date>1988-01-29</date><risdate>1988</risdate><volume>84</volume><issue>1</issue><spage>20</spage><epage>25</epage><pages>20-25</pages><issn>0002-9343</issn><eissn>1555-7162</eissn><abstract>This study quantified the immediate general hemodynamic events following the bilateral carotid ligation-induced cerebral ischemia in normotensive and spontaneously hypertensive rats. The influence of treatment with indapamide was evaluated. In normotensive rats, hemodynamic values remained unchanged during the 10 minutes following the carotid ligation. In spontaneously hypertensive rats, arterial pressure values immediately and significantly (p <0.01) increased, up to 50 percent during the 10 minutes following the carotid ligation. Heart rate was unchanged. Indapamide at a short-term 3 mg/kg intraperitoneally, chosen in order to give a minimal (non-significant) antihypertensive effect in spontaneously hypertensive rats, significantly (p <0.01) reduced the bilateral carotid ligation-induced vasopressor response, whereas heart rate remained unchanged. The results presented here show that in spontaneously hypertensive rats, but not in normotensive rats, bilateral common carotid ligation induces an immediate and strong increase in arterial pressure values. These results compare with the previously described differences in cerebral ischemia-induced disorders in normotensive and hypertensive rats. Finally, indapamide, an antihypertensive agent that decreases vascular reactivity, significantly inhibits the carotid ligation-induced vasopressive response in hypertensive rats.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>3341387</pmid><doi>10.1016/0002-9343(88)90808-X</doi><tpages>6</tpages></addata></record> |
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| ispartof | The American journal of medicine, 1988-01, Vol.84 (1), p.20-25 |
| issn | 0002-9343 1555-7162 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Brain Ischemia - drug therapy Brain Ischemia - etiology Brain Ischemia - physiopathology Disease Models, Animal Diuretics - therapeutic use Dose-Response Relationship, Drug Drug Evaluation, Preclinical Hemodynamics - drug effects Hypertension - complications Hypertension - drug therapy Hypertension - physiopathology Indapamide - administration & dosage Indapamide - therapeutic use Injections, Intraperitoneal Male Rats Rats, Inbred SHR Rats, Inbred Strains Time Factors |
| title | Effect of indapamide on an experimental model of cerebral ischemia in hypertensive rats |
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