Effect of indapamide on an experimental model of cerebral ischemia in hypertensive rats

This study quantified the immediate general hemodynamic events following the bilateral carotid ligation-induced cerebral ischemia in normotensive and spontaneously hypertensive rats. The influence of treatment with indapamide was evaluated. In normotensive rats, hemodynamic values remained unchanged...

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Veröffentlicht in:	The American journal of medicine 1988-01, Vol.84 (1), p.20-25
Hauptverfasser:	Delbarre, Bernard, Delbarre, Gisèle
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Ischemia - drug therapy Brain Ischemia - etiology Brain Ischemia - physiopathology Disease Models, Animal Diuretics - therapeutic use Dose-Response Relationship, Drug Drug Evaluation, Preclinical Hemodynamics - drug effects Hypertension - complications Hypertension - drug therapy Hypertension - physiopathology Indapamide - administration & dosage Indapamide - therapeutic use Injections, Intraperitoneal Male Rats Rats, Inbred SHR Rats, Inbred Strains Time Factors
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Beschreibung
Zusammenfassung:	This study quantified the immediate general hemodynamic events following the bilateral carotid ligation-induced cerebral ischemia in normotensive and spontaneously hypertensive rats. The influence of treatment with indapamide was evaluated. In normotensive rats, hemodynamic values remained unchanged during the 10 minutes following the carotid ligation. In spontaneously hypertensive rats, arterial pressure values immediately and significantly (p
ISSN:	0002-9343 1555-7162
DOI:	10.1016/0002-9343(88)90808-X