Diagnostic Usefulness of Linear and Nonlinear Quantitative EEG Analysis in Alzheimer's Disease
The sensitivity of the EEG in early AD is somewhat limited. In this respect spectral analysis is little better than visual assessment. In this study we address the question whether a new type of EEG analysis derived from chaos theory can improve the sensitivity of the EEG. EEGs were recorded in 15 c...
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Veröffentlicht in: | Clinical EEG and neuroscience 1996-04, Vol.27 (2), p.69-77 |
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description | The sensitivity of the EEG in early AD is somewhat limited. In this respect spectral analysis is little better than visual assessment. In this study we address the question whether a new type of EEG analysis derived from chaos theory can improve the sensitivity of the EEG. EEGs were recorded in 15 control subjects and 15 patients with mild AD. The EEG recorded at 02 and 01 during eyes closed and eyes open conditions was subjected to spectral analysis (relative power) and nonlinear analysis (calculation of the correlation dimension D2). AD patients had more relative theta power and impaired reactivity in alpha, delta and theta bands. Also, reactivity of the D2 was impaired in AD subjects. For a specificity of 100%, relative theta power had the highest sensitivity (46.7%). Alpha band reactivity at O1 had a sensitivity of 40% and D2 reactivity at O1 had a sensitivity of 33.3%. Combining theta power with alpha reactivity resulted in a sensitivity of 53.3%; combining theta with D2 reactivity resulted in a sensitivity of 60%. Used in isolation, linear analysis was superior in differentiating AD patients from controls. The best results were obtained by combining linear with nonlinear measures. This approach does not seem practical yet, but deserves further study. |
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J. ; Jelles, B. ; Achtereekte, H. A. M. ; van Birgelen, J. H. ; Slaets, J. P. J.</creator><creatorcontrib>Stam, C. J. ; Jelles, B. ; Achtereekte, H. A. M. ; van Birgelen, J. H. ; Slaets, J. P. J.</creatorcontrib><description>The sensitivity of the EEG in early AD is somewhat limited. In this respect spectral analysis is little better than visual assessment. In this study we address the question whether a new type of EEG analysis derived from chaos theory can improve the sensitivity of the EEG. EEGs were recorded in 15 control subjects and 15 patients with mild AD. The EEG recorded at 02 and 01 during eyes closed and eyes open conditions was subjected to spectral analysis (relative power) and nonlinear analysis (calculation of the correlation dimension D2). AD patients had more relative theta power and impaired reactivity in alpha, delta and theta bands. Also, reactivity of the D2 was impaired in AD subjects. For a specificity of 100%, relative theta power had the highest sensitivity (46.7%). Alpha band reactivity at O1 had a sensitivity of 40% and D2 reactivity at O1 had a sensitivity of 33.3%. Combining theta power with alpha reactivity resulted in a sensitivity of 53.3%; combining theta with D2 reactivity resulted in a sensitivity of 60%. Used in isolation, linear analysis was superior in differentiating AD patients from controls. The best results were obtained by combining linear with nonlinear measures. 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Prion diseases ; Discriminant analysis ; Dominance, Cerebral - physiology ; EEG ; Electroencephalography - instrumentation ; Female ; Fourier Analysis ; Humans ; Male ; Medical diagnosis ; Medical sciences ; Middle Aged ; Neurodegenerative diseases ; Neurology ; Noise ; Reference Values ; Sensory Deprivation - physiology ; Signal Processing, Computer-Assisted - instrumentation ; Studies ; Theta Rhythm ; Time series</subject><ispartof>Clinical EEG and neuroscience, 1996-04, Vol.27 (2), p.69-77</ispartof><rights>1996 EEG and Clinical Neuroscience Society</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c395t-2864bc6d911f0e3cbe0d5a03ce58875d58ea7a51dfb27b0ff8468ddde94b65053</citedby><cites>FETCH-LOGICAL-c395t-2864bc6d911f0e3cbe0d5a03ce58875d58ea7a51dfb27b0ff8468ddde94b65053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/155005949602700205$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/155005949602700205$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>309,310,314,776,780,785,786,21798,23909,23910,25118,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3031844$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8681465$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stam, C. J.</creatorcontrib><creatorcontrib>Jelles, B.</creatorcontrib><creatorcontrib>Achtereekte, H. A. M.</creatorcontrib><creatorcontrib>van Birgelen, J. H.</creatorcontrib><creatorcontrib>Slaets, J. P. J.</creatorcontrib><title>Diagnostic Usefulness of Linear and Nonlinear Quantitative EEG Analysis in Alzheimer's Disease</title><title>Clinical EEG and neuroscience</title><addtitle>Clin Electroencephalogr</addtitle><description>The sensitivity of the EEG in early AD is somewhat limited. In this respect spectral analysis is little better than visual assessment. In this study we address the question whether a new type of EEG analysis derived from chaos theory can improve the sensitivity of the EEG. EEGs were recorded in 15 control subjects and 15 patients with mild AD. The EEG recorded at 02 and 01 during eyes closed and eyes open conditions was subjected to spectral analysis (relative power) and nonlinear analysis (calculation of the correlation dimension D2). AD patients had more relative theta power and impaired reactivity in alpha, delta and theta bands. Also, reactivity of the D2 was impaired in AD subjects. For a specificity of 100%, relative theta power had the highest sensitivity (46.7%). Alpha band reactivity at O1 had a sensitivity of 40% and D2 reactivity at O1 had a sensitivity of 33.3%. Combining theta power with alpha reactivity resulted in a sensitivity of 53.3%; combining theta with D2 reactivity resulted in a sensitivity of 60%. Used in isolation, linear analysis was superior in differentiating AD patients from controls. The best results were obtained by combining linear with nonlinear measures. This approach does not seem practical yet, but deserves further study.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alzheimer Disease - diagnosis</subject><subject>Alzheimer Disease - physiopathology</subject><subject>Alzheimer's disease</subject><subject>Arousal - physiology</subject><subject>Biological and medical sciences</subject><subject>Chaos theory</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Discriminant analysis</subject><subject>Dominance, Cerebral - physiology</subject><subject>EEG</subject><subject>Electroencephalography - instrumentation</subject><subject>Female</subject><subject>Fourier Analysis</subject><subject>Humans</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurodegenerative diseases</subject><subject>Neurology</subject><subject>Noise</subject><subject>Reference Values</subject><subject>Sensory Deprivation - physiology</subject><subject>Signal Processing, Computer-Assisted - instrumentation</subject><subject>Studies</subject><subject>Theta Rhythm</subject><subject>Time series</subject><issn>0009-9155</issn><issn>1550-0594</issn><issn>2169-5202</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kNFrFDEQxoMo9aj9BwQhoNintZPsJps8Hu3ZCoci2FeXbDKpKXvZmtkt1L_eLXcUUXwahu8338x8jL0W8EGItj0TSgEo21gNsgWQoJ6xlRTaVkqCfM5WAGAru2Av2QnRLTz2LQiwR-zIaCMarVbs-0VyN3mkKXl-TRjnISMRHyPfpoyucJcD_zzmYd99nV2e0uSmdI98s7nk6-yGB0rEU-br4dcPTDssp8QvEqEjfMVeRDcQnhzqMbv-uPl2flVtv1x-Ol9vK19bNVXS6Kb3OlghImDte4SgHNQelTGtCsqga50SIfay7SFG02gTQkDb9FqBqo_Z-73vXRl_zkhTt0vkcRhcxnGmrjVgQUu7gG__Am_HuSxPUCesMbWqwYiFknvKl5GoYOzuStq58tAJ6B7T7_5Nfxl6c7Ce-x2Gp5FD1ov-7qA78m6IxWWf6AmroRamaRbsbI-Ru8E_rvv_4t_37ZhN</recordid><startdate>19960401</startdate><enddate>19960401</enddate><creator>Stam, C. J.</creator><creator>Jelles, B.</creator><creator>Achtereekte, H. A. M.</creator><creator>van Birgelen, J. H.</creator><creator>Slaets, J. P. J.</creator><general>SAGE Publications</general><general>ECNS</general><general>SAGE PUBLICATIONS, INC</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>19960401</creationdate><title>Diagnostic Usefulness of Linear and Nonlinear Quantitative EEG Analysis in Alzheimer's Disease</title><author>Stam, C. J. ; Jelles, B. ; Achtereekte, H. A. M. ; van Birgelen, J. H. ; Slaets, J. P. J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c395t-2864bc6d911f0e3cbe0d5a03ce58875d58ea7a51dfb27b0ff8468ddde94b65053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alzheimer Disease - diagnosis</topic><topic>Alzheimer Disease - physiopathology</topic><topic>Alzheimer's disease</topic><topic>Arousal - physiology</topic><topic>Biological and medical sciences</topic><topic>Chaos theory</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Discriminant analysis</topic><topic>Dominance, Cerebral - physiology</topic><topic>EEG</topic><topic>Electroencephalography - instrumentation</topic><topic>Female</topic><topic>Fourier Analysis</topic><topic>Humans</topic><topic>Male</topic><topic>Medical diagnosis</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurodegenerative diseases</topic><topic>Neurology</topic><topic>Noise</topic><topic>Reference Values</topic><topic>Sensory Deprivation - physiology</topic><topic>Signal Processing, Computer-Assisted - instrumentation</topic><topic>Studies</topic><topic>Theta Rhythm</topic><topic>Time series</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stam, C. J.</creatorcontrib><creatorcontrib>Jelles, B.</creatorcontrib><creatorcontrib>Achtereekte, H. A. M.</creatorcontrib><creatorcontrib>van Birgelen, J. H.</creatorcontrib><creatorcontrib>Slaets, J. P. 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J.</au><au>Jelles, B.</au><au>Achtereekte, H. A. M.</au><au>van Birgelen, J. H.</au><au>Slaets, J. P. J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic Usefulness of Linear and Nonlinear Quantitative EEG Analysis in Alzheimer's Disease</atitle><jtitle>Clinical EEG and neuroscience</jtitle><addtitle>Clin Electroencephalogr</addtitle><date>1996-04-01</date><risdate>1996</risdate><volume>27</volume><issue>2</issue><spage>69</spage><epage>77</epage><pages>69-77</pages><issn>0009-9155</issn><issn>1550-0594</issn><eissn>2169-5202</eissn><abstract>The sensitivity of the EEG in early AD is somewhat limited. In this respect spectral analysis is little better than visual assessment. In this study we address the question whether a new type of EEG analysis derived from chaos theory can improve the sensitivity of the EEG. EEGs were recorded in 15 control subjects and 15 patients with mild AD. The EEG recorded at 02 and 01 during eyes closed and eyes open conditions was subjected to spectral analysis (relative power) and nonlinear analysis (calculation of the correlation dimension D2). AD patients had more relative theta power and impaired reactivity in alpha, delta and theta bands. Also, reactivity of the D2 was impaired in AD subjects. For a specificity of 100%, relative theta power had the highest sensitivity (46.7%). Alpha band reactivity at O1 had a sensitivity of 40% and D2 reactivity at O1 had a sensitivity of 33.3%. Combining theta power with alpha reactivity resulted in a sensitivity of 53.3%; combining theta with D2 reactivity resulted in a sensitivity of 60%. Used in isolation, linear analysis was superior in differentiating AD patients from controls. The best results were obtained by combining linear with nonlinear measures. This approach does not seem practical yet, but deserves further study.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>8681465</pmid><doi>10.1177/155005949602700205</doi><tpages>9</tpages></addata></record> |
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subjects | Aged Aged, 80 and over Alzheimer Disease - diagnosis Alzheimer Disease - physiopathology Alzheimer's disease Arousal - physiology Biological and medical sciences Chaos theory Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Discriminant analysis Dominance, Cerebral - physiology EEG Electroencephalography - instrumentation Female Fourier Analysis Humans Male Medical diagnosis Medical sciences Middle Aged Neurodegenerative diseases Neurology Noise Reference Values Sensory Deprivation - physiology Signal Processing, Computer-Assisted - instrumentation Studies Theta Rhythm Time series |
title | Diagnostic Usefulness of Linear and Nonlinear Quantitative EEG Analysis in Alzheimer's Disease |
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