The effect of hydroxyl radical scavenging on acute axial-random skin flap survival

Dimethyl thiourea (DMTU), a known hydroxyl radical scavenger, was tested for its ability to improve survival in acute island skin flaps. Rats receiving 500 mg/kg DMTU 1 hour after flap elevation showed a 23.5% improved survival over saline controls. The role of the hydroxyl radical in ischemia/reper...

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Veröffentlicht in:	The Laryngoscope 1988-01, Vol.98 (1), p.106-108
Hauptverfasser:	Hayden, Richard E., Paniello, Randal C., Bello, Steven L., Yeung, Cecil S. T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Biological and medical sciences Exact sciences and technology Graft Survival - drug effects Hydroxides - metabolism Hydroxyl Radical Male Medical sciences Microcirculation - drug effects Other techniques and industries Pharmacology. Drug treatments Rats Rats, Inbred Strains Skin - blood supply Skin - metabolism Skin, nail, hair, dermoskeleton Surgical Flaps Thiourea - analogs & derivatives Thiourea - pharmacology
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Beschreibung
Zusammenfassung:	Dimethyl thiourea (DMTU), a known hydroxyl radical scavenger, was tested for its ability to improve survival in acute island skin flaps. Rats receiving 500 mg/kg DMTU 1 hour after flap elevation showed a 23.5% improved survival over saline controls. The role of the hydroxyl radical in ischemia/reperfusion injury, and its proposed mechanism, is discussed.
ISSN:	0023-852X 1531-4995
DOI:	10.1288/00005537-198801000-00021