Antagonistic Adrenergic-Muscarinic Regulation of M Current in Smooth Muscle Cells

The $\beta $-adrenergic agonist isoproterenol and analogs of adenosine 3$^{\prime}$,5$^{\prime}$-monophosphate (cAMP) induced a potassium current, M current, in freshly dissociated gastric smooth muscle cells. Muscarinic agonists suppress this current, apparently by acting at a locus downstream from...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1988-01, Vol.239 (4836), p.190-193
Hauptverfasser:	Sims, Stephen M., Singer, Joshua J., Walsh, John V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine - pharmacology Agonists Animals Biochemistry Biological and medical sciences Bufo marinus Cyclic AMP - physiology Electric Conductivity Electric current Electric potential Fundamental and applied biological sciences. Psychology In Vitro Techniques Ion channels Isoproterenol - pharmacology Medical research Membrane potential Membrane Potentials - drug effects Muscarine - pharmacology Muscle cells Muscle, Smooth - physiology Neurons Neurotransmitters Physiological regulation Pipettes potassium Potassium - physiology Receptors, Adrenergic, beta - physiology Receptors, Muscarinic - physiology Smooth muscle Smooth muscle myocytes Steady state current stomach Stomach - physiology Striated muscle. Tendons Vertebrates: osteoarticular system, musculoskeletal system
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Beschreibung
Zusammenfassung:	The $\beta $-adrenergic agonist isoproterenol and analogs of adenosine 3$^{\prime}$,5$^{\prime}$-monophosphate (cAMP) induced a potassium current, M current, in freshly dissociated gastric smooth muscle cells. Muscarinic agonists suppress this current, apparently by acting at a locus downstream from regulation of cAMP levels by adenylate cyclase and phosphodiesterase. Thus, M current can be induced by an agent and regulated in antagonistic fashion by $\beta $-adrenergic and muscarinic systems.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.2827305