Stimulation of DNA synthesis in serum-starved NIL-8 cells by unilamellar liposomes

Stimulation of DNA synthesis in serum-starved NIL-8 cells by unilamellar liposomes

Unilamellar liposomes added to serum-starved NIL-8 hamster fibroblasts stimulate DNA synthesis in 18 to 46% of the populations. Stimulation of DNA synthesis depends on the type and composition of liposomes. The highest rate of stimulation was observed on addition of 50 mu g/ml of unilamellar liposom...

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Veröffentlicht in:Acta biochimica polonica 1982, Vol.29 (1-2), p.105-110
1. Verfasser: Gardas, A
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Blood
Cell Line
Cholesterol - pharmacology
Cricetinae
DNA - biosynthesis
fibroblasts
Fibroblasts - drug effects
Fibroblasts - metabolism
hamsters
liposomes
Liposomes - pharmacology
Phosphatidic Acids - pharmacology
Phosphatidylcholines - pharmacology
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Zusammenfassung:Unilamellar liposomes added to serum-starved NIL-8 hamster fibroblasts stimulate DNA synthesis in 18 to 46% of the populations. Stimulation of DNA synthesis depends on the type and composition of liposomes. The highest rate of stimulation was observed on addition of 50 mu g/ml of unilamellar liposomes composed of lecitin, cholesterol and phosphatidic acid at the 10:5:1 ratio. Multilamellar liposomes added at the same concentration did not stimulate DNA synthesis.
ISSN:0001-527X