Modelization of coordinated changes of adenylate energy charge and ATP/ADP ratio : application to energy metabolism in invertebrate and vertebrate skeletal muscle

Regulation of the coordinated adenylate energy charge (AEC) and ATP/ADP ratio variations was studied with the aid of computer-made simulations. When the equilibrium state for the adenylate kinase-catalyzed reaction has been assumed, the function describing the coordinated AEC and ATP/ADP ratio varia...

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Veröffentlicht in:	Comptes rendus de l'Académie des sciences, Série III, Sciences de la vie Série III, Sciences de la vie, 1996, Vol.319 (1), p.9-15
Hauptverfasser:	RAFFIN, J.-P, THEBAULT, M.-T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - analysis Adenosine Monophosphate - metabolism Adenosine Triphosphate - analysis Adenylate Kinase - pharmacokinetics AMP Deaminase - pharmacokinetics Animals Biological and medical sciences Cell physiology Computer Simulation Energy Metabolism Freshwater Fundamental and applied biological sciences. Psychology Humans Invertebrata Invertebrates - metabolism Marine Models, Biological Molecular and cellular biology Muscle contraction Muscle, Skeletal - metabolism Rats Vertebrata Vertebrates - metabolism
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Zusammenfassung:	Regulation of the coordinated adenylate energy charge (AEC) and ATP/ADP ratio variations was studied with the aid of computer-made simulations. When the equilibrium state for the adenylate kinase-catalyzed reaction has been assumed, the function describing the coordinated AEC and ATP/ADP ratio variations can be simply derived from the formulas describing these 2 parameters. The model was used to analyze incidence of AMP deamination in the coordinated regulation of cellular energy metabolism.
ISSN:	0764-4469