Hybrid biphenotypic acute leukemia with extreme hypodiploidy

A patient diagnosed as having acute lymphoblastic leukemia (L2) relapsed 4 months later and was found to have morphologic and immunologic evidence of a biphenotypic hybrid acute leukemia. Chromosome analysis at relapse showed two abnormal clones, one with marked hypodiploidy and the other with exact...

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Veröffentlicht in:	Pathology 1987-04, Vol.19 (2), p.197-200
Hauptverfasser:	Tallents, Stephen, Forster, Donald C., Margaret Garson, O., Michael, Patricia M., Briggs, Peter, Brodie, Graham N., Pilkington, Glenn, Januszewicz, Elchanan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal - immunology Cell Line Chromosome Aberrations - pathology Chromosome Disorders Diploidy Humans hypodiploid Karyotyping Leukemia Leukemia, Lymphoid - diagnosis Leukemia, Lymphoid - pathology lymphoblastic Male monocytic nonlymphoblastic Phenotype
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Beschreibung
Zusammenfassung:	A patient diagnosed as having acute lymphoblastic leukemia (L2) relapsed 4 months later and was found to have morphologic and immunologic evidence of a biphenotypic hybrid acute leukemia. Chromosome analysis at relapse showed two abnormal clones, one with marked hypodiploidy and the other with exactly double the hypodiploid clone. It is considered that this is an example of a hybrid lymphoblastic/nonlymphoblastic leukemia with unique karyotype.
ISSN:	0031-3025 1465-3931
DOI:	10.3109/00313028709077134