Effect of cortical kindling on [ 3H] d-aspartate uptake and glutamate metabolism in rats

The effects of cortical kindling in rats on [ 3H] d-aspartate uptake and on glutaminase and glutamine synthetase activities has been studied. The high affinity uptake of [ 3H] d-aspartate in control cortical tissue ( K m approximately 2 μM) was undetectable in the kindled tissue, whilst the enzyme activities were unchanged. A loss of the high-affinity uptake sites for excitatory amino acids may be a contributing factor to the kindling phenomenon. kwElectrical kindling; Cerebral cortex; [ 3H] d-aspartate uptake; Glutaminase-glutamine synthetase