The frequency of C4B variants of complement in familial and sporadic Alzheimer disease

A previous study reported an unexpected increased frequency of the uncommon C4B2 allele of complement in a group of patients with senile dementia of the Alzheimer type. We compared the frequency of various C4B types in 25 patients with familial Alzheimer dementia (AD), 22 patients with sporadic AD,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Alzheimer disease and associated disorders 1987, Vol.1 (4), p.251-255
Hauptverfasser: BIRD, T. D, BOEHNKE, M, ANDERSON, J, LAMPE, T. H, SCHELLENBERG, G, LARSON, E. B
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 255
container_issue 4
container_start_page 251
container_title Alzheimer disease and associated disorders
container_volume 1
creator BIRD, T. D
BOEHNKE, M
ANDERSON, J
LAMPE, T. H
SCHELLENBERG, G
LARSON, E. B
description A previous study reported an unexpected increased frequency of the uncommon C4B2 allele of complement in a group of patients with senile dementia of the Alzheimer type. We compared the frequency of various C4B types in 25 patients with familial Alzheimer dementia (AD), 22 patients with sporadic AD, and 360 control individuals. Neither Alzheimer group showed any significant increase or decrease in the frequency of C4B alleles compared with controls. We were unable to confirm any association between AD and the C4B2 allele.
doi_str_mv 10.1097/00002093-198701040-00004
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78050426</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78050426</sourcerecordid><originalsourceid>FETCH-LOGICAL-c254t-141683ba0806f3b88c443706f2a0a0b1bfa976027cc08965356114ef00845a9f3</originalsourceid><addsrcrecordid>eNo9kMtKAzEUhoMotVYfQchC3I2eTK6zrMUbCG7U7XAmTWhkLjVphfr0prY2i5Nz-f6E8xNCGdwwqPQt5FNCxQtWGQ0MBBTbljgiYyaFKgST6piMwWQEuGCn5Cylz0xoLmFERjmWslJj8vG2cNRH97V2vd3QwdOZuKPfGAP2q7St7dAtW9e5fkVDTz12oQ3YUuznNC2HiPNg6bT9WbjQuUjnITlM7pyceGyTu9jfE_L-cP82eypeXh-fZ9OXwpZSrAommDK8QTCgPG-MsUJwnfMSAaFhjcdKKyi1tXkVJblUjAnnAYyQWHk-Ide7d5dxyCukVd2FZF3bYu-Gdaq1AQmiVBk0O9DGIaXofL2MocO4qRnUW0vrf0vrg6V_LZGll_s_1k3n5gfh3sM8v9rPMVlsfcTehnTAtNayKoH_AtHdfF8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78050426</pqid></control><display><type>article</type><title>The frequency of C4B variants of complement in familial and sporadic Alzheimer disease</title><source>MEDLINE</source><source>Journals@Ovid Complete</source><creator>BIRD, T. D ; BOEHNKE, M ; ANDERSON, J ; LAMPE, T. H ; SCHELLENBERG, G ; LARSON, E. B</creator><creatorcontrib>BIRD, T. D ; BOEHNKE, M ; ANDERSON, J ; LAMPE, T. H ; SCHELLENBERG, G ; LARSON, E. B</creatorcontrib><description>A previous study reported an unexpected increased frequency of the uncommon C4B2 allele of complement in a group of patients with senile dementia of the Alzheimer type. We compared the frequency of various C4B types in 25 patients with familial Alzheimer dementia (AD), 22 patients with sporadic AD, and 360 control individuals. Neither Alzheimer group showed any significant increase or decrease in the frequency of C4B alleles compared with controls. We were unable to confirm any association between AD and the C4B2 allele.</description><identifier>ISSN: 0893-0341</identifier><identifier>EISSN: 1546-4156</identifier><identifier>DOI: 10.1097/00002093-198701040-00004</identifier><identifier>PMID: 3502596</identifier><identifier>CODEN: ADADE2</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams &amp; Wilkins</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alleles ; Alzheimer Disease - genetics ; Alzheimer Disease - immunology ; Biological and medical sciences ; Complement C4 - genetics ; Complement C4b ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Gene Frequency ; Humans ; Male ; Medical sciences ; Middle Aged ; Neurology</subject><ispartof>Alzheimer disease and associated disorders, 1987, Vol.1 (4), p.251-255</ispartof><rights>1988 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c254t-141683ba0806f3b88c443706f2a0a0b1bfa976027cc08965356114ef00845a9f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=7775920$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3502596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BIRD, T. D</creatorcontrib><creatorcontrib>BOEHNKE, M</creatorcontrib><creatorcontrib>ANDERSON, J</creatorcontrib><creatorcontrib>LAMPE, T. H</creatorcontrib><creatorcontrib>SCHELLENBERG, G</creatorcontrib><creatorcontrib>LARSON, E. B</creatorcontrib><title>The frequency of C4B variants of complement in familial and sporadic Alzheimer disease</title><title>Alzheimer disease and associated disorders</title><addtitle>Alzheimer Dis Assoc Disord</addtitle><description>A previous study reported an unexpected increased frequency of the uncommon C4B2 allele of complement in a group of patients with senile dementia of the Alzheimer type. We compared the frequency of various C4B types in 25 patients with familial Alzheimer dementia (AD), 22 patients with sporadic AD, and 360 control individuals. Neither Alzheimer group showed any significant increase or decrease in the frequency of C4B alleles compared with controls. We were unable to confirm any association between AD and the C4B2 allele.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - immunology</subject><subject>Biological and medical sciences</subject><subject>Complement C4 - genetics</subject><subject>Complement C4b</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><issn>0893-0341</issn><issn>1546-4156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtKAzEUhoMotVYfQchC3I2eTK6zrMUbCG7U7XAmTWhkLjVphfr0prY2i5Nz-f6E8xNCGdwwqPQt5FNCxQtWGQ0MBBTbljgiYyaFKgST6piMwWQEuGCn5Cylz0xoLmFERjmWslJj8vG2cNRH97V2vd3QwdOZuKPfGAP2q7St7dAtW9e5fkVDTz12oQ3YUuznNC2HiPNg6bT9WbjQuUjnITlM7pyceGyTu9jfE_L-cP82eypeXh-fZ9OXwpZSrAommDK8QTCgPG-MsUJwnfMSAaFhjcdKKyi1tXkVJblUjAnnAYyQWHk-Ide7d5dxyCukVd2FZF3bYu-Gdaq1AQmiVBk0O9DGIaXofL2MocO4qRnUW0vrf0vrg6V_LZGll_s_1k3n5gfh3sM8v9rPMVlsfcTehnTAtNayKoH_AtHdfF8</recordid><startdate>1987</startdate><enddate>1987</enddate><creator>BIRD, T. D</creator><creator>BOEHNKE, M</creator><creator>ANDERSON, J</creator><creator>LAMPE, T. H</creator><creator>SCHELLENBERG, G</creator><creator>LARSON, E. B</creator><general>Lippincott Williams &amp; Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1987</creationdate><title>The frequency of C4B variants of complement in familial and sporadic Alzheimer disease</title><author>BIRD, T. D ; BOEHNKE, M ; ANDERSON, J ; LAMPE, T. H ; SCHELLENBERG, G ; LARSON, E. B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c254t-141683ba0806f3b88c443706f2a0a0b1bfa976027cc08965356114ef00845a9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer Disease - immunology</topic><topic>Biological and medical sciences</topic><topic>Complement C4 - genetics</topic><topic>Complement C4b</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><toplevel>online_resources</toplevel><creatorcontrib>BIRD, T. D</creatorcontrib><creatorcontrib>BOEHNKE, M</creatorcontrib><creatorcontrib>ANDERSON, J</creatorcontrib><creatorcontrib>LAMPE, T. H</creatorcontrib><creatorcontrib>SCHELLENBERG, G</creatorcontrib><creatorcontrib>LARSON, E. B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alzheimer disease and associated disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BIRD, T. D</au><au>BOEHNKE, M</au><au>ANDERSON, J</au><au>LAMPE, T. H</au><au>SCHELLENBERG, G</au><au>LARSON, E. B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The frequency of C4B variants of complement in familial and sporadic Alzheimer disease</atitle><jtitle>Alzheimer disease and associated disorders</jtitle><addtitle>Alzheimer Dis Assoc Disord</addtitle><date>1987</date><risdate>1987</risdate><volume>1</volume><issue>4</issue><spage>251</spage><epage>255</epage><pages>251-255</pages><issn>0893-0341</issn><eissn>1546-4156</eissn><coden>ADADE2</coden><abstract>A previous study reported an unexpected increased frequency of the uncommon C4B2 allele of complement in a group of patients with senile dementia of the Alzheimer type. We compared the frequency of various C4B types in 25 patients with familial Alzheimer dementia (AD), 22 patients with sporadic AD, and 360 control individuals. Neither Alzheimer group showed any significant increase or decrease in the frequency of C4B alleles compared with controls. We were unable to confirm any association between AD and the C4B2 allele.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams &amp; Wilkins</pub><pmid>3502596</pmid><doi>10.1097/00002093-198701040-00004</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0893-0341
ispartof Alzheimer disease and associated disorders, 1987, Vol.1 (4), p.251-255
issn 0893-0341
1546-4156
language eng
recordid cdi_proquest_miscellaneous_78050426
source MEDLINE; Journals@Ovid Complete
subjects Adult
Aged
Aged, 80 and over
Alleles
Alzheimer Disease - genetics
Alzheimer Disease - immunology
Biological and medical sciences
Complement C4 - genetics
Complement C4b
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Gene Frequency
Humans
Male
Medical sciences
Middle Aged
Neurology
title The frequency of C4B variants of complement in familial and sporadic Alzheimer disease
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T13%3A31%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20frequency%20of%20C4B%20variants%20of%20complement%20in%20familial%20and%20sporadic%20Alzheimer%20disease&rft.jtitle=Alzheimer%20disease%20and%20associated%20disorders&rft.au=BIRD,%20T.%20D&rft.date=1987&rft.volume=1&rft.issue=4&rft.spage=251&rft.epage=255&rft.pages=251-255&rft.issn=0893-0341&rft.eissn=1546-4156&rft.coden=ADADE2&rft_id=info:doi/10.1097/00002093-198701040-00004&rft_dat=%3Cproquest_cross%3E78050426%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78050426&rft_id=info:pmid/3502596&rfr_iscdi=true