The frequency of C4B variants of complement in familial and sporadic Alzheimer disease

A previous study reported an unexpected increased frequency of the uncommon C4B2 allele of complement in a group of patients with senile dementia of the Alzheimer type. We compared the frequency of various C4B types in 25 patients with familial Alzheimer dementia (AD), 22 patients with sporadic AD,...

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Veröffentlicht in:	Alzheimer disease and associated disorders 1987, Vol.1 (4), p.251-255
Hauptverfasser:	BIRD, T. D, BOEHNKE, M, ANDERSON, J, LAMPE, T. H, SCHELLENBERG, G, LARSON, E. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Alzheimer Disease - genetics Alzheimer Disease - immunology Biological and medical sciences Complement C4 - genetics Complement C4b Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Gene Frequency Humans Male Medical sciences Middle Aged Neurology
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Zusammenfassung:	A previous study reported an unexpected increased frequency of the uncommon C4B2 allele of complement in a group of patients with senile dementia of the Alzheimer type. We compared the frequency of various C4B types in 25 patients with familial Alzheimer dementia (AD), 22 patients with sporadic AD, and 360 control individuals. Neither Alzheimer group showed any significant increase or decrease in the frequency of C4B alleles compared with controls. We were unable to confirm any association between AD and the C4B2 allele.
ISSN:	0893-0341 1546-4156
DOI:	10.1097/00002093-198701040-00004