Mode of antibacterial action of totarol, a diterpene from Podocarpus nagi

Abstract The antimicrobial mechanism of totarol was studied using PSEUDOMONAS AERUGINOSA IFO 3080. This diterpene inhibited oxygen consumption and respiratory-driven proton trans-location in whole cells, and oxidation of NADH in membrane preparation. NADH-cytochrome C reductase was inhibited by tota...

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Veröffentlicht in:	Planta medica 1996-04, Vol.62 (2), p.122-125
Hauptverfasser:	Haraguchi, H, Oike, S, Muroi, H, Kuba, I. (Fukuyama Univ. (Japan). Faculty of Engineering)
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology ANTIMICROBIAL PROPERTIES Biological and medical sciences Cell Membrane - metabolism CHEMICAL COMPOSITION CHEMICAL STRUCTURE COMPOSICION QUIMICA COMPOSITION CHIMIQUE Diterpenes - pharmacology DITERPENOIDE DITERPENOIDS DITERPENOS DRUG PLANTS Electron Transport - drug effects Electron Transport Complex I Electron Transport Complex IV - metabolism Escherichia coli - drug effects ESTRUCTURA QUIMICA FARMACOLOGIA General pharmacology INHIBICION INHIBITION Medical sciences Microbial Sensitivity Tests NAD - metabolism NADH Dehydrogenase - antagonists & inhibitors NADH, NADPH Oxidoreductases - antagonists & inhibitors NADH, NADPH Oxidoreductases - metabolism Oxygen Consumption - drug effects Pharmacognosy. Homeopathy. Health food PHARMACOLOGIE PHARMACOLOGY Pharmacology. Drug treatments Plant Extracts Plant Roots PLANTAS MEDICINALES PLANTE MEDICINALE PODOCARPUS PROPIEDADES ANTIMICROBIANAS PROPRIETE ANTIMICROBIENNE Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - metabolism RESPIRATORY DISORDERS Staphylococcus aureus - drug effects STRUCTURE CHIMIQUE TRASTORNOS RESPIRATORIOS TROUBLE RESPIRATOIRE
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Zusammenfassung:	Abstract The antimicrobial mechanism of totarol was studied using PSEUDOMONAS AERUGINOSA IFO 3080. This diterpene inhibited oxygen consumption and respiratory-driven proton trans-location in whole cells, and oxidation of NADH in membrane preparation. NADH-cytochrome C reductase was inhibited by totarol while cytochrome C oxidase was not. NADH-DPIP reductase and NADH-CoQ reductase were also inhibited. The site of respiratory inhibition of totarol was thought to be near CoQ in the bacterial electron transport chain.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2006-957832