Expression of Hel-N1 and HeL-N2 in small-cell lung carcinoma
Hel‐Nl and HuD are neuron‐specific RNA‐binding proteins that are antigenic targets of anti‐Hu antibodies. Although expression of Hu antigens is most commonly seen in small‐cell lung carcinoma, their exact identity (e.g., Hel‐N1, HeLN2, HuD, and HuC) cannot be distinguished by immunological methods....
Gespeichert in:
| Veröffentlicht in: | Annals of neurology 1996-05, Vol.39 (5), p.679-681 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 681 |
|---|---|
| container_issue | 5 |
| container_start_page | 679 |
| container_title | Annals of neurology |
| container_volume | 39 |
| creator | King, Peter H. Dropcho, Edward J. |
| description | Hel‐Nl and HuD are neuron‐specific RNA‐binding proteins that are antigenic targets of anti‐Hu antibodies. Although expression of Hu antigens is most commonly seen in small‐cell lung carcinoma, their exact identity (e.g., Hel‐N1, HeLN2, HuD, and HuC) cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this distinctian. Here we demonstrate that Hel‐Nl and Hel‐N2 are expressed in small‐cell lung carcinoma using reverse transcription‐polymerase chain reaction. |
| doi_str_mv | 10.1002/ana.410390520 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78017455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78017455</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4030-151122ac9dcbdf6113f257d4a043534a15c61128902c325e13d5c1492e22cf6c3</originalsourceid><addsrcrecordid>eNp9kMtLw0AQxhdRan0cPQo5iLetM_vIA7yUolUpEcTHcVk3G4lukrprsP73pjQUT55mmO83Mx8fIScIEwRgF7rRE4HAM5AMdsgYJUeaMpHtkjHwWFCJXOyTgxDeASCLEUZklMaYSRmPyeXVaultCFXbRG0Z3VhHc4x0U_TtguYsqpoo1No5aqxzkeuat8hob6qmrfUR2Su1C_Z4qIfk6frqcXZDF_fz29l0QY0ADhQlImPaZIV5LcoYkZdMJoXQILjkQqM0_ZClGTDDmbTIC2lQZMwyZsrY8ENyvrm79O1nZ8OXqquw9qMb23ZBJSlgIqTsQboBjW9D8LZUS1_V2v8oBLVOS_VpqW1aPX86HO5ea1ts6SGeXj8bdB2MdqXXjanCFuOQgsC0x5IN9l05-_P_TzXNp38NDIar8GVX203tP1Sc8ESql3yuZncPqXieP6s7_gvrc41p</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78017455</pqid></control><display><type>article</type><title>Expression of Hel-N1 and HeL-N2 in small-cell lung carcinoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>King, Peter H. ; Dropcho, Edward J.</creator><creatorcontrib>King, Peter H. ; Dropcho, Edward J.</creatorcontrib><description>Hel‐Nl and HuD are neuron‐specific RNA‐binding proteins that are antigenic targets of anti‐Hu antibodies. Although expression of Hu antigens is most commonly seen in small‐cell lung carcinoma, their exact identity (e.g., Hel‐N1, HeLN2, HuD, and HuC) cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this distinctian. Here we demonstrate that Hel‐Nl and Hel‐N2 are expressed in small‐cell lung carcinoma using reverse transcription‐polymerase chain reaction.</description><identifier>ISSN: 0364-5134</identifier><identifier>EISSN: 1531-8249</identifier><identifier>DOI: 10.1002/ana.410390520</identifier><identifier>PMID: 8619556</identifier><identifier>CODEN: ANNED3</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Base Sequence ; Biological and medical sciences ; Carcinoma, Small Cell - genetics ; DNA Primers - genetics ; ELAV Proteins ; ELAV-Like Protein 2 ; ELAV-Like Protein 4 ; Gene Expression Regulation, Neoplastic - physiology ; Humans ; Isomerism ; Leukemia, Erythroblastic, Acute ; Lung Neoplasms - genetics ; Medical sciences ; Molecular Sequence Data ; Nerve Tissue Proteins - genetics ; Pneumology ; Polymerase Chain Reaction ; RNA-Binding Proteins - genetics ; Tumor Cells, Cultured - physiology ; Tumors of the respiratory system and mediastinum</subject><ispartof>Annals of neurology, 1996-05, Vol.39 (5), p.679-681</ispartof><rights>Copyright © 1996 American Neurological Association</rights><rights>1996 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4030-151122ac9dcbdf6113f257d4a043534a15c61128902c325e13d5c1492e22cf6c3</citedby><cites>FETCH-LOGICAL-c4030-151122ac9dcbdf6113f257d4a043534a15c61128902c325e13d5c1492e22cf6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fana.410390520$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fana.410390520$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27915,27916,45565,45566</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3080418$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8619556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>King, Peter H.</creatorcontrib><creatorcontrib>Dropcho, Edward J.</creatorcontrib><title>Expression of Hel-N1 and HeL-N2 in small-cell lung carcinoma</title><title>Annals of neurology</title><addtitle>Ann Neurol</addtitle><description>Hel‐Nl and HuD are neuron‐specific RNA‐binding proteins that are antigenic targets of anti‐Hu antibodies. Although expression of Hu antigens is most commonly seen in small‐cell lung carcinoma, their exact identity (e.g., Hel‐N1, HeLN2, HuD, and HuC) cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this distinctian. Here we demonstrate that Hel‐Nl and Hel‐N2 are expressed in small‐cell lung carcinoma using reverse transcription‐polymerase chain reaction.</description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Small Cell - genetics</subject><subject>DNA Primers - genetics</subject><subject>ELAV Proteins</subject><subject>ELAV-Like Protein 2</subject><subject>ELAV-Like Protein 4</subject><subject>Gene Expression Regulation, Neoplastic - physiology</subject><subject>Humans</subject><subject>Isomerism</subject><subject>Leukemia, Erythroblastic, Acute</subject><subject>Lung Neoplasms - genetics</subject><subject>Medical sciences</subject><subject>Molecular Sequence Data</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Pneumology</subject><subject>Polymerase Chain Reaction</subject><subject>RNA-Binding Proteins - genetics</subject><subject>Tumor Cells, Cultured - physiology</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0364-5134</issn><issn>1531-8249</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtLw0AQxhdRan0cPQo5iLetM_vIA7yUolUpEcTHcVk3G4lukrprsP73pjQUT55mmO83Mx8fIScIEwRgF7rRE4HAM5AMdsgYJUeaMpHtkjHwWFCJXOyTgxDeASCLEUZklMaYSRmPyeXVaultCFXbRG0Z3VhHc4x0U_TtguYsqpoo1No5aqxzkeuat8hob6qmrfUR2Su1C_Z4qIfk6frqcXZDF_fz29l0QY0ADhQlImPaZIV5LcoYkZdMJoXQILjkQqM0_ZClGTDDmbTIC2lQZMwyZsrY8ENyvrm79O1nZ8OXqquw9qMb23ZBJSlgIqTsQboBjW9D8LZUS1_V2v8oBLVOS_VpqW1aPX86HO5ea1ts6SGeXj8bdB2MdqXXjanCFuOQgsC0x5IN9l05-_P_TzXNp38NDIar8GVX203tP1Sc8ESql3yuZncPqXieP6s7_gvrc41p</recordid><startdate>199605</startdate><enddate>199605</enddate><creator>King, Peter H.</creator><creator>Dropcho, Edward J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Willey-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199605</creationdate><title>Expression of Hel-N1 and HeL-N2 in small-cell lung carcinoma</title><author>King, Peter H. ; Dropcho, Edward J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4030-151122ac9dcbdf6113f257d4a043534a15c61128902c325e13d5c1492e22cf6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Small Cell - genetics</topic><topic>DNA Primers - genetics</topic><topic>ELAV Proteins</topic><topic>ELAV-Like Protein 2</topic><topic>ELAV-Like Protein 4</topic><topic>Gene Expression Regulation, Neoplastic - physiology</topic><topic>Humans</topic><topic>Isomerism</topic><topic>Leukemia, Erythroblastic, Acute</topic><topic>Lung Neoplasms - genetics</topic><topic>Medical sciences</topic><topic>Molecular Sequence Data</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Pneumology</topic><topic>Polymerase Chain Reaction</topic><topic>RNA-Binding Proteins - genetics</topic><topic>Tumor Cells, Cultured - physiology</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>King, Peter H.</creatorcontrib><creatorcontrib>Dropcho, Edward J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>King, Peter H.</au><au>Dropcho, Edward J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Hel-N1 and HeL-N2 in small-cell lung carcinoma</atitle><jtitle>Annals of neurology</jtitle><addtitle>Ann Neurol</addtitle><date>1996-05</date><risdate>1996</risdate><volume>39</volume><issue>5</issue><spage>679</spage><epage>681</epage><pages>679-681</pages><issn>0364-5134</issn><eissn>1531-8249</eissn><coden>ANNED3</coden><abstract>Hel‐Nl and HuD are neuron‐specific RNA‐binding proteins that are antigenic targets of anti‐Hu antibodies. Although expression of Hu antigens is most commonly seen in small‐cell lung carcinoma, their exact identity (e.g., Hel‐N1, HeLN2, HuD, and HuC) cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this distinctian. Here we demonstrate that Hel‐Nl and Hel‐N2 are expressed in small‐cell lung carcinoma using reverse transcription‐polymerase chain reaction.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>8619556</pmid><doi>10.1002/ana.410390520</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0364-5134 |
| ispartof | Annals of neurology, 1996-05, Vol.39 (5), p.679-681 |
| issn | 0364-5134 1531-8249 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78017455 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Base Sequence Biological and medical sciences Carcinoma, Small Cell - genetics DNA Primers - genetics ELAV Proteins ELAV-Like Protein 2 ELAV-Like Protein 4 Gene Expression Regulation, Neoplastic - physiology Humans Isomerism Leukemia, Erythroblastic, Acute Lung Neoplasms - genetics Medical sciences Molecular Sequence Data Nerve Tissue Proteins - genetics Pneumology Polymerase Chain Reaction RNA-Binding Proteins - genetics Tumor Cells, Cultured - physiology Tumors of the respiratory system and mediastinum |
| title | Expression of Hel-N1 and HeL-N2 in small-cell lung carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T07%3A02%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20Hel-N1%20and%20HeL-N2%20in%20small-cell%20lung%20carcinoma&rft.jtitle=Annals%20of%20neurology&rft.au=King,%20Peter%20H.&rft.date=1996-05&rft.volume=39&rft.issue=5&rft.spage=679&rft.epage=681&rft.pages=679-681&rft.issn=0364-5134&rft.eissn=1531-8249&rft.coden=ANNED3&rft_id=info:doi/10.1002/ana.410390520&rft_dat=%3Cproquest_cross%3E78017455%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=78017455&rft_id=info:pmid/8619556&rfr_iscdi=true |