Expression of Hel-N1 and HeL-N2 in small-cell lung carcinoma

Hel‐Nl and HuD are neuron‐specific RNA‐binding proteins that are antigenic targets of anti‐Hu antibodies. Although expression of Hu antigens is most commonly seen in small‐cell lung carcinoma, their exact identity (e.g., Hel‐N1, HeLN2, HuD, and HuC) cannot be distinguished by immunological methods....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of neurology 1996-05, Vol.39 (5), p.679-681
Hauptverfasser:	King, Peter H., Dropcho, Edward J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Biological and medical sciences Carcinoma, Small Cell - genetics DNA Primers - genetics ELAV Proteins ELAV-Like Protein 2 ELAV-Like Protein 4 Gene Expression Regulation, Neoplastic - physiology Humans Isomerism Leukemia, Erythroblastic, Acute Lung Neoplasms - genetics Medical sciences Molecular Sequence Data Nerve Tissue Proteins - genetics Pneumology Polymerase Chain Reaction RNA-Binding Proteins - genetics Tumor Cells, Cultured - physiology Tumors of the respiratory system and mediastinum
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Hel‐Nl and HuD are neuron‐specific RNA‐binding proteins that are antigenic targets of anti‐Hu antibodies. Although expression of Hu antigens is most commonly seen in small‐cell lung carcinoma, their exact identity (e.g., Hel‐N1, HeLN2, HuD, and HuC) cannot be distinguished by immunological methods. Analysis of messenger RNA expression is needed for this distinctian. Here we demonstrate that Hel‐Nl and Hel‐N2 are expressed in small‐cell lung carcinoma using reverse transcription‐polymerase chain reaction.
ISSN:	0364-5134 1531-8249
DOI:	10.1002/ana.410390520