Antascomicins A, B, C, D and E Novel FKBP12 Binding Compounds from a Micromonospora Strain

5 novel ascomycin-like compounds, antascomicins A, B, C, D and E were isolated from a strain of Micromonospora. The antascomicins bind strongly to the FK506-binding protein FKBP12 and antagonize the immunosuppressive activity of FK506 and rapamycin. The strain description, fermentation, structure el...

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Veröffentlicht in:	Journal of antibiotics 1996/03/25, Vol.49(3), pp.230-233
Hauptverfasser:	FEHR, THEODOR, SANGLIER, JEAN-JACQUES, SCHULER, WALTER, GSCHWIND, LILIANE, PONELLE, MONIQUE, SCHILLING, WOLFGANG, WLOLAND, CATHERINE
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - antagonists & inhibitors Biological and medical sciences Carrier Proteins - metabolism Cattle DNA-Binding Proteins - metabolism Heat-Shock Proteins - metabolism Humans Immunosuppressive Agents - antagonists & inhibitors In Vitro Techniques Magnetic Resonance Spectroscopy Medical sciences Micromonospora - metabolism Miscellaneous Molecular Structure Pharmacology. Drug treatments Polyenes - antagonists & inhibitors Polyenes - pharmacology Sirolimus Tacrolimus - analogs & derivatives Tacrolimus - antagonists & inhibitors Tacrolimus - chemistry Tacrolimus - metabolism Tacrolimus - pharmacology Tacrolimus Binding Proteins
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Zusammenfassung:	5 novel ascomycin-like compounds, antascomicins A, B, C, D and E were isolated from a strain of Micromonospora. The antascomicins bind strongly to the FK506-binding protein FKBP12 and antagonize the immunosuppressive activity of FK506 and rapamycin. The strain description, fermentation, structure elucidation and biological activity of these compounds are described.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.49.230