Novel 28-kDa secretory protein from rat olfactory epithelium

We have isolated a novel secretory 28-kDa protein which is an abundant component of the rat olfactory mucosa. The partial sequence of the 28-kDa protein has been determined. The amino acid sequence of the 28-kDa protein is similar to that of non-selenium glutathione peroxidase from bovine ciliary bo...

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Veröffentlicht in:	FEBS letters 1996-02, Vol.381 (1), p.12-14
Hauptverfasser:	Peshenko, I.V., Novoselov, V.I., Evdokimov, V.A., Nikolaev, Yu.V., Shuvaeva, T.M., Lipkin, V.M., Fesenko, E.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	28-kDa protein Amino Acid Sequence Animals Antibodies Cattle Chromatography, Gel Electrophoresis, Polyacrylamide Gel Epithelium - metabolism Glutathione Glutathione peroxidase Glutathione Peroxidase - biosynthesis Glutathione Peroxidase - chemistry Glutathione Peroxidase - isolation & purification Isoenzymes - biosynthesis Isoenzymes - chemistry Isoenzymes - isolation & purification Methionine - metabolism Molecular Sequence Data Molecular Weight Olfactory epithelium Olfactory Mucosa - metabolism Organ Specificity Rabbits - immunology Rat Rats Sequence Homology, Amino Acid Sulfur Radioisotopes
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Zusammenfassung:	We have isolated a novel secretory 28-kDa protein which is an abundant component of the rat olfactory mucosa. The partial sequence of the 28-kDa protein has been determined. The amino acid sequence of the 28-kDa protein is similar to that of non-selenium glutathione peroxidase from bovine ciliary body. The 28-kDa protein catalyzed decomposition of the hydrogen peroxide as well as organic hydroperoxides by reduced glutathion and seems to be a member of the glutathion peroxidases family.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(96)00071-3