Immunity to Acanthamoeba culbertsoni: experimental studies with Acanthamoeba and control antigen preparations

Mice were intranasally immunized with living and killed Acanthamoeba as well as culture supernatant, living Toxoplasma and BCG, and challenged with pathogenic A. culbertsoni strain A-1. The best protection was achieved with killed amoebae of the same strain. A high rate of mortality was observed in...

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Veröffentlicht in:	Transactions of the Royal Society of Tropical Medicine and Hygiene 1987-01, Vol.81 (5), p.768-770
Hauptverfasser:	Bhaduri, C.R., Janitschke, K., Masihi, K.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acanthamoeba - immunology Acanthamoeba culbertsoni Administration, Intranasal Amebiasis - prevention & control Amibiasis Animals Antigens, Protozoan - immunology Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences Fundamental and applied biological sciences. Psychology Human protozoal diseases Immunization Infectious diseases Medical sciences Mice Parasitic diseases Protozoa Protozoal diseases Toxoplasma Tropical medicine
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Beschreibung
Zusammenfassung:	Mice were intranasally immunized with living and killed Acanthamoeba as well as culture supernatant, living Toxoplasma and BCG, and challenged with pathogenic A. culbertsoni strain A-1. The best protection was achieved with killed amoebae of the same strain. A high rate of mortality was observed in immunized mice treated with immunosuppressives and challenged with A. culbertsoni A-1. The significance of the results in relation to environmental human infection is discussed.
ISSN:	0035-9203 1878-3503
DOI:	10.1016/0035-9203(87)90026-5