Case of acute monocytic leukemia with 47,XY, +X,t(2;10) (q21.1;q26.1) and basophilia

The clinical and cytogenetic findings of a patient with acute monocytic leukemia with peripheral and bone marrow basophilia are presented. The cytogenetic analysis of bone marrow cells established a pathologic clone with the following unusual karyotype: 47,XY, +X,t(2;10)(q21.1;q26.1). This chromosom...

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Veröffentlicht in:	Cancer genetics and cytogenetics 1996, Vol.86 (1), p.80-82
Hauptverfasser:	Mitev, Lubomir, Apostolov, Peter, Manolova, Yanka
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Basophils - pathology Biological and medical sciences Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 2 Hematologic and hematopoietic diseases Humans Karyotyping Leukemia, Monocytic, Acute - drug therapy Leukemia, Monocytic, Acute - genetics Leukemia, Monocytic, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Sex Chromosome Aberrations Translocation, Genetic X Chromosome
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Zusammenfassung:	The clinical and cytogenetic findings of a patient with acute monocytic leukemia with peripheral and bone marrow basophilia are presented. The cytogenetic analysis of bone marrow cells established a pathologic clone with the following unusual karyotype: 47,XY, +X,t(2;10)(q21.1;q26.1). This chromosome abnormality has not been reported previously in leukemic diseases.
ISSN:	0165-4608 1873-4456
DOI:	10.1016/0165-4608(95)00056-9