Localization and ordering of acid alpha-glucosidase (GAA) and thymidine kinase (TK1) by fluorescence in situ hybridization

Genomic DNA clones of human acid alpha glucosidase (GAA) and thymidine kinase (TK1) were used to map the exact location and order of these genes on human chromosome 17. Both genes were localized to the 17q25-qter band (17q25.2-q25.3), with GAA distal to TK1. They were also shown to be, respectively,...

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Veröffentlicht in:	Human genetics 1996-03, Vol.97 (3), p.404-406
Hauptverfasser:	KUO, W.-L, HIRSCHHORN, R, HUIE, M. L, HIRSCHHORN, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 17 - genetics Classical genetics, quantitative genetics, hybrids Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Glucosidases - genetics Human Humans In Situ Hybridization, Fluorescence Thymidine Kinase - genetics
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Beschreibung
Zusammenfassung:	Genomic DNA clones of human acid alpha glucosidase (GAA) and thymidine kinase (TK1) were used to map the exact location and order of these genes on human chromosome 17. Both genes were localized to the 17q25-qter band (17q25.2-q25.3), with GAA distal to TK1. They were also shown to be, respectively, distal and proximal to an anonymous cosmid (cK17.71) previously mapped to this region.
ISSN:	0340-6717 1432-1203
DOI:	10.1007/BF02185782