Growth factor production after polytetrafluoroethylene and vein arterial grafting: an experimental study

Purpose: Occlusion caused by myointimal hyperplasia appears to be the main reason of late failure of polytetrafluoroethylene (PTFE) arterial bypass grafts. Evidence exists that growth factors are involved in the genesis of myointimal hyperplasia. The aim of this study was to assess the release of pl...

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Veröffentlicht in:	Journal of vascular surgery 1996-03, Vol.23 (3), p.453-460
Hauptverfasser:	Sterpetti, Antonio V., Lepidi, Sandro, Cucina, Alessandra, Patrizi, Anna L., Palumbo, Roberta, Taranta, Anna, Stipa, Francesco, Cavallaro, Antonino, Santoro-D'Angelo, Luciana, Stipa, Sergio
Format:	Artikel
Sprache:	eng
Schlagworte:	Anastomosis, Surgical Animals Aorta, Abdominal - pathology Aorta, Abdominal - surgery Biological and medical sciences Blood Vessel Prosthesis Graft Occlusion, Vascular Growth Substances - analysis Growth Substances - biosynthesis Hyperplasia - etiology Hyperplasia - pathology Male Medical sciences Polytetrafluoroethylene Rats Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tunica Intima - pathology Vascular surgery: aorta, extremities, vena cava. Surgery of the lymphatic vessels Vena Cava, Inferior - pathology Vena Cava, Inferior - transplantation
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Zusammenfassung:	Purpose: Occlusion caused by myointimal hyperplasia appears to be the main reason of late failure of polytetrafluoroethylene (PTFE) arterial bypass grafts. Evidence exists that growth factors are involved in the genesis of myointimal hyperplasia. The aim of this study was to assess the release of platelet-derived growth factor (PDGF) and basic fibroblastic growth factor (bFGF) by PTFE arterial grafts. Methods: Results: Conclusions:
ISSN:	0741-5214 1097-6809
DOI:	10.1016/S0741-5214(96)80010-3