Antibody-Mediated Neutrophil Depletion Preserves Pulmonary Vasomotor Function

Antibody-Mediated Neutrophil Depletion Preserves Pulmonary Vasomotor Function

Neutrophil depletion is commonly used to examine the role of neutrophils in lung injury. However, the effect of neutrophil depletion per se on mechanisms of pulmonary vascular smooth muscle relaxation is unknown. The purpose of this study was to examine the effect of neutropenia on the following mec...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:The Journal of surgical research 1996-04, Vol.62 (1), p.74-78
Hauptverfasser: Sheridan, Brett C., McIntyre, Jr, Robert C., Meldrum, Daniel R., Cleveland, Jr, Joseph C., Agrafojo, Jeanette, Eisenach, John H., Harken, Alden H., Fullerton, David A.
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholine - pharmacology
Animals
Biological and medical sciences
Blood vessels and receptors
Calcimycin - pharmacology
Cyclic GMP - physiology
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiology
Fundamental and applied biological sciences. Psychology
Immune Sera
Lung - blood supply
Male
Muscle Relaxation - drug effects
Muscle, Smooth, Vascular - drug effects
Muscle, Smooth, Vascular - physiology
Neutropenia
Neutrophils - immunology
Neutrophils - physiology
Nitroprusside - pharmacology
Rats
Rats, Sprague-Dawley
Vasomotor System - physiology
Vertebrates: cardiovascular system
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Neutrophil depletion is commonly used to examine the role of neutrophils in lung injury. However, the effect of neutrophil depletion per se on mechanisms of pulmonary vascular smooth muscle relaxation is unknown. The purpose of this study was to examine the effect of neutropenia on the following mechanisms of cGMP-mediated pulmonary vasorelaxation: (1) receptor-dependent endothelium-dependent relaxation (response to acetylcholine (ACh)), (2) receptor-independent endothelium-dependent relaxation (response to the calcium ionophore A23187), and (3) endothelium-independent relaxation (response to sodium nitroprusside (SNP)). Neutropenia (
ISSN:0022-4804
1095-8673
DOI:10.1006/jsre.1996.0176