Extending the recognition site of designed minor groove binding molecules

Extending the recognition site of designed minor groove binding molecules

A linked, imazole/pyrrole minor-groove ligand has been shown to bind sequence specif icially to a 13 base-pair target sequence in a mixed 1:1/2:1 mode.

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Bibliographische Detailangaben
Veröffentlicht in:Nature Structural Biology 1996-04, Vol.3 (4), p.321-324
Hauptverfasser: Geierstanger, Bernhard H, Mrksich, Milan, Dervan, Peter B, Wemmer, David E
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
Binding Sites
Biochemistry
Biological Microscopy
Biomedical and Life Sciences
correspondence
DNA - chemistry
DNA - metabolism
Life Sciences
Ligands
Membrane Biology
Models, Molecular
Molecular Sequence Data
Oligodeoxyribonucleotides - metabolism
Protein Structure
Pyrroles - chemistry
Pyrroles - metabolism
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Beschreibung
Zusammenfassung:A linked, imazole/pyrrole minor-groove ligand has been shown to bind sequence specif icially to a 13 base-pair target sequence in a mixed 1:1/2:1 mode.
ISSN:1072-8368
1545-9993
2331-365X
1545-9985
DOI:10.1038/nsb0496-321