Inhibitor sensitivity of respiratory complex I in human platelets: A possible biomarker of ageing

NADH-Coenzyme Q reductase was assayed in platelet mitochondrial membranes obtained from 19 pools of two venous blood samples from female young (19–30 years) individuals and 18 pools from aged ones (66–107 years). The enzyme activities were not significantly changed in the two groups, but a decrease...

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Veröffentlicht in:	FEBS letters 1996-02, Vol.380 (1), p.176-178
Hauptverfasser:	Merlo Pich, M., Bovina, C., Formiggini, G., Cometti, G.G., Ghelli, A., Parenti Castelli, G., Genova, M.L., Marchetti, M., Semeraro, S., Lenaz, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Ageing Aging - physiology Biomarkers Blood Platelets - physiology Complex I Electron Transport Complex I Enzyme Inhibitors - pharmacology Female Humans Mitochondria - physiology NADH, NADPH Oxidoreductases - antagonists & inhibitors Platelet mitochondrion Rotenone - pharmacology Rotenone sensitivity
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Zusammenfassung:	NADH-Coenzyme Q reductase was assayed in platelet mitochondrial membranes obtained from 19 pools of two venous blood samples from female young (19–30 years) individuals and 18 pools from aged ones (66–107 years). The enzyme activities were not significantly changed in the two groups, but a decrease of sensitivity to the specific inhibitor, rotenone, occurred in a substantial number of aged individuals. The results are in agreement with the predictions of the mitochondrial theory of ageing and may be used to develop a sensitive biomarker of the ageing process.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(96)00037-3