Nucleotide sequences of three tRNA(Ser) from Drosophila melanogaster reading the six serine codons

The nucleotide sequences of three serine tRNAs from Drosophila melanogaster, together capable of decoding the six serine codons, were determined. tRNA(Ser)2b has the anticodon GCU, tRNA(Ser)4 has CGA and tRNA(Ser)7 has IGA. tRNA(Ser)2b differs from the last two by about 25%. However, tRNA(Ser)4 and...

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Veröffentlicht in:	Journal of molecular biology 1987-10, Vol.197 (3), p.389-395
Hauptverfasser:	Cribbs, D.L, Gillam, I.C, Tener, G.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticodon Base Sequence Biological Evolution Codon Drosophila melanogaster Drosophila melanogaster - genetics Genes Molecular Sequence Data Nucleic Acid Conformation nucleotide sequences RNA RNA, Fungal - genetics RNA, Transfer, Amino Acid-Specific - genetics RNA, Transfer, Ser - genetics Saccharomyces cerevisiae - genetics Schizosaccharomyces - genetics Sequence Homology, Nucleic Acid yeasts
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Zusammenfassung:	The nucleotide sequences of three serine tRNAs from Drosophila melanogaster, together capable of decoding the six serine codons, were determined. tRNA(Ser)2b has the anticodon GCU, tRNA(Ser)4 has CGA and tRNA(Ser)7 has IGA. tRNA(Ser)2b differs from the last two by about 25%. However, tRNA(Ser)4 and tRNA(Ser)7 are 96% homologous, differing only at the first position of the anticodon and two other sites. This unusual sequence relationship suggests, together with similar pairs in the yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae, that eukaryotic tRNA(Ser)UCN may be undergoing concerted evolution.
ISSN:	0022-2836 1089-8638
DOI:	10.1016/0022-2836(87)90552-3