A Role for CD81 in Early T Cell Development
Early stages of T cell development are thought to include a series of coordinated interactions between thymocytes and other cells of the thymus. A monoclonal antibody specific for mouse CD81 was identified that blocked the appearance of αβ but not γδ T cells in fetal organ cultures initiated with da...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1996-01, Vol.271 (5246), p.198-200 |
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| creator | Boismenu, Richard Rhein, Maria Fischer, Wolfgang H. Havran, Wendy L. |
| description | Early stages of T cell development are thought to include a series of coordinated interactions between thymocytes and other cells of the thymus. A monoclonal antibody specific for mouse CD81 was identified that blocked the appearance of αβ but not γδ T cells in fetal organ cultures initiated with day 14.5 thymus lobes. In reaggregation cultures with CD81-transfected fibroblasts, CD4$^-$ CD8$^-$ thymocytes differentiated into CD4$^+$ CD8$^+$ T cells. Thus, interactions between immature thymocytes and stromal cells expressing CD81 are required and may be sufficient to induce early events associated with T cell development. |
| doi_str_mv | 10.1126/science.271.5246.198 |
| format | Article |
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Psychology ; Fundamental immunology ; Immunity (Disease) ; Immunobiology ; Ligands ; Lymphatic system ; Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation ; Medical research ; Membrane Proteins - immunology ; Membrane Proteins - physiology ; Mice ; Molecular Sequence Data ; Organ Culture Techniques ; Pregnancy ; Receptors, Antigen, T-Cell, alpha-beta - analysis ; Receptors, Antigen, T-Cell, gamma-delta - analysis ; Spleen cells ; Stromal cells ; Stromal Cells - immunology ; T cell antigen receptors ; T cells ; T lymphocytes ; T-Lymphocyte Subsets - cytology ; T-Lymphocyte Subsets - immunology ; Tetraspanin 28 ; Thymocytes ; Thymus Gland - cytology ; Thymus Gland - immunology ; Transfection</subject><ispartof>Science (American Association for the Advancement of Science), 1996-01, Vol.271 (5246), p.198-200</ispartof><rights>Copyright 1996 American Association for the Advancement of Science</rights><rights>1996 INIST-CNRS</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1996 American Association for the Advancement of Science</rights><rights>Copyright American Association for the Advancement of Science Jan 12, 1996</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c746t-372d50a18fd3de439b9dad72dc81adab30d12ad79afc31d27e69ba1d3bdbe3dc3</citedby><cites>FETCH-LOGICAL-c746t-372d50a18fd3de439b9dad72dc81adab30d12ad79afc31d27e69ba1d3bdbe3dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2889539$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2889539$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2974198$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8539618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boismenu, Richard</creatorcontrib><creatorcontrib>Rhein, Maria</creatorcontrib><creatorcontrib>Fischer, Wolfgang H.</creatorcontrib><creatorcontrib>Havran, Wendy L.</creatorcontrib><title>A Role for CD81 in Early T Cell Development</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Early stages of T cell development are thought to include a series of coordinated interactions between thymocytes and other cells of the thymus. A monoclonal antibody specific for mouse CD81 was identified that blocked the appearance of αβ but not γδ T cells in fetal organ cultures initiated with day 14.5 thymus lobes. In reaggregation cultures with CD81-transfected fibroblasts, CD4$^-$ CD8$^-$ thymocytes differentiated into CD4$^+$ CD8$^+$ T cells. Thus, interactions between immature thymocytes and stromal cells expressing CD81 are required and may be sufficient to induce early events associated with T cell development.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigens, CD - genetics</subject><subject>Antigens, CD - immunology</subject><subject>Antigens, CD - physiology</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>CD4 Antigens - analysis</subject><subject>CD8 Antigens - analysis</subject><subject>Cell Differentiation</subject><subject>Cell lines</subject><subject>CHO Cells</subject><subject>Cricetinae</subject><subject>Cultured cells</subject><subject>Developmental Stages</subject><subject>Differentiation</subject><subject>Epithelial cells</subject><subject>Fundamental and applied biological sciences. 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A monoclonal antibody specific for mouse CD81 was identified that blocked the appearance of αβ but not γδ T cells in fetal organ cultures initiated with day 14.5 thymus lobes. In reaggregation cultures with CD81-transfected fibroblasts, CD4$^-$ CD8$^-$ thymocytes differentiated into CD4$^+$ CD8$^+$ T cells. Thus, interactions between immature thymocytes and stromal cells expressing CD81 are required and may be sufficient to induce early events associated with T cell development.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>8539618</pmid><doi>10.1126/science.271.5246.198</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1996-01, Vol.271 (5246), p.198-200 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77965987 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Amino Acid Sequence Animals Antibodies, Monoclonal - immunology Antigens, CD - genetics Antigens, CD - immunology Antigens, CD - physiology Base Sequence Biological and medical sciences CD4 Antigens - analysis CD8 Antigens - analysis Cell Differentiation Cell lines CHO Cells Cricetinae Cultured cells Developmental Stages Differentiation Epithelial cells Fundamental and applied biological sciences. Psychology Fundamental immunology Immunity (Disease) Immunobiology Ligands Lymphatic system Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation Medical research Membrane Proteins - immunology Membrane Proteins - physiology Mice Molecular Sequence Data Organ Culture Techniques Pregnancy Receptors, Antigen, T-Cell, alpha-beta - analysis Receptors, Antigen, T-Cell, gamma-delta - analysis Spleen cells Stromal cells Stromal Cells - immunology T cell antigen receptors T cells T lymphocytes T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology Tetraspanin 28 Thymocytes Thymus Gland - cytology Thymus Gland - immunology Transfection |
| title | A Role for CD81 in Early T Cell Development |
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