Renal abnormalities in mutant mice

On endothelial surfaces throughout the body, angiotensin-converting enzyme (ACE) generates angiotensin II and other peptides which contribute to fluid and electrolyte balance and to the maintenance of blood pressure. ACE is also expressed in tissues from early embryonic stages, including epithelia, where its role is poorly defined. We have been particularly interested in potential roles of ACE in development, because pharmacological blockade in neonatal rats can cause renal abnormalities. Targeted mutation of the ACE gene has recently been shown to reduce blood pressure in heterozygous mice and to produce infertility in homozygous deficient male mice, accompanied by renal cortical atrophy, tubular shrinkage and inflammation. Adult mice of all genotypes appear otherwise outwardly healthy.